Compartmental models of growing neurites
Compartmental models of growing neurites
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DOI：
10.1016/s0925-2312(01)00463-5
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发表时间：
2001-06-01
期刊：
影响因子：
6
通讯作者：
van Ooyen, A
中科院分区：
文献类型：
--
作者：
Graham, BP;van Ooyen, A
为了使用计算机模型研究神经元的形态和电发育，扩展房室建模框架以包括神经突（树突和轴突）可能随时间改变其长度、直径和膜特征的情况是有用的。这需要在特定的计算机模拟期间改变现有隔间的大小和其他属性并添加新隔间。我们一直关注的是，当生长锥中的物质浓度控制神经突的伸长和分支时，神经突的生长模型。这种物质在索马中产生，并沿着生长的神经突扩散或主动运输。我们描述了这种情况的房室模型所涉及的技术问题。(C)2001 Elsevier Science B.V.保留所有权利。
To investigate the morphological and electrical development of neurons using computer models it is useful to extend the compartmental modelling framework to include the situation where neurites (dendrites and axons) may change their length, diameter and membrane characteristics over time. This requires changing the size and other properties of existing compartments and adding new compartments during a particular computer simulation. We have been concerned with modelling the outgrowth of neurites when elongation and branching are controlled by the concentration of a substance in the growth cones. The substance is produced in the soma and diffuses or is actively transported along the growing neurites. We describe the technical issues involved in the compartmental modelling of this situation. (C) 2001 Elsevier Science B.V. All rights reserved.