Copper-mediated annulative direct coupling of o-alkynylphenols with oxadiazoles: a dehydrogenative cascade construction of biheteroaryls.
Copper-mediated annulative direct coupling of o-alkynylphenols with oxadiazoles: a dehydrogenative cascade construction of biheteroaryls.
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DOI：
10.1021/ol200975j
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发表时间：
2011-05
期刊：
影响因子：
5.2
通讯作者：
Hitoshi Hachiya;K. Hirano;T. Satoh;M. Miura
中科院分区：
文献类型：
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作者：
Hitoshi Hachiya;K. Hirano;T. Satoh;M. Miura
邻炔基苯酚与1，3，4-恶二唑在铜催化下的直接环化偶联反应在室温下也能顺利进行，得到相应的双杂芳基化合物。该反应体系代表了一种新的途径，其生物学和物理性质的利益的联杂芳基分子的建设。
A copper-mediated annulative direct coupling of o-alkynylphenols with 1,3,4-oxadiazoles proceeds smoothly even under ambient conditions to afford the corresponding biheteroaryls. The reaction system represents a new avenue for the construction of biheteroaryl molecules of interest in their biological and physical properties.