Dietary consistency and craniofacial development related to masticatory function in minipigs.
Dietary consistency and craniofacial development related to masticatory function in minipigs.
复制标题
小型猪的饮食一致性和颅面发育与咀嚼功能有关。
DOI：
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发表时间：
1997
期刊：
影响因子：
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通讯作者：
R. Corruccini
中科院分区：
文献类型：
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作者：
R. Ciochon;Nisbett Ra;R. Corruccini
自19世纪90年代以来，口腔生物学研究人员一直对剧烈咀嚼未加工的食物会刺激适当的口面部生长和咬合关系的想法感兴趣。相反，由于食用精制食物而缺乏这种功能是工业化人类咬合不正病因学的许多假设之一。对这一想法的严格控制的实验测试仅限于老鼠。为了研究“废用”理论在一个更大的身体和咬合相关的动物模型，我们提出了四个尤卡坦小型猪断奶硬饮食（HD）和另外四个软化，但相当的饮食（SD）。动物监测8个月，处死，然后收集咬合和骨测量数据。由于饮食制度的变化是普遍的，而不是由于龋齿，牙周炎，或磨损的差异。然而，HD体重比SD大10%，深咬肌大25%，浅咬肌和颞肌重量也有类似的比例失调。两组患者的面颌畸形、牙弓狭窄、牙齿拥挤/萌出不良和后颅尖变细有显著差异。一个奇怪的后方扭转的差异，在下颌支，以及广泛和平坦的下颌联合，也发生在SD。我们对样本的19个记录变量进行了Q模式主坐标分析，自举变量列表，以证明统计学显著性（P < .01）的显著差异的总体模式。控制其他著名的正畸病因（遗传背景，呼吸模式，感染性变性和邻间磨损），这些结果支持的命题，饮食的一致性直接关系到人类颅面生长。
Since the 1890s oral biological researchers have been interested in the idea that strenuous mastication of unprocessed food will stimulate proper oral-facial growth and occlusal relationships. Conversely, lack of such function due to consumption of refined food is one hypothesis among many for the etiology of malocclusion in industrialized humans. Adequately controlled experimental testing of the idea has been limited to rats. To investigate the "disuse" theory in a larger-bodied and more occlusally relevant animal model, we raised four Yucatan minipigs from weaning on hard diet (HD) and another four on softened but equivalent diet (SD). The animals were monitored for eight months, sacrificed, and then occlusal and osteometric data collected. Variations due to dietary regime are pervasive and not due to caries, periodontitis, or attrition differences. Whereas HD body weight is 10% greater than SD, the deep masseter is 25% greater, with similar disproportion in superficial masseter and temporalis weight. Facial prognathism, arch narrowness, tooth crowding/maleruption and posterior cranial tapering are markedly different in the two groups. A curious posterior torsional difference in the mandibular rami, as well as broadness and flatness of the mandibular symphysis, also occur in SD. We performed a Q-mode principal coordinates analysis of the 19 logged variables for the specimens, bootstrapping the variable list, to demonstrate a statistically significant (P < .01) overall pattern of dramatic differences. Having controlled other celebrated orthodontic etiologies (genetic background, respiratory mode, infectious degeneration and interproximal attrition), these results support the proposition that dietary consistency relates directly to human craniofacial growth.