Clinical findings and imaging features of 67 nasopharyngeal carcinoma patients with postradiation nasopharyngeal necrosis.
Clinical findings and imaging features of 67 nasopharyngeal carcinoma patients with postradiation nasopharyngeal necrosis.
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67例鼻咽癌放射后鼻咽坏死患者的临床表现及影像学特征
DOI：
10.5732/cjc.012.10252
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发表时间：
2013-10
影响因子：
--
通讯作者：
Hua YJ
中科院分区：
文献类型：
--
作者：
Chen MY;Mai HQ;Sun R;Guo X;Zhao C;Hong MH;Hua YJ
放疗后鼻咽坏死是放疗的重要晚期效应，影响鼻咽癌患者的预后。本研究回顾性分析2006年6月至2010年1月中山大学肿瘤防治中心收治的67例经病理诊断为放射后鼻咽坏死患者的临床及影像学特征，分析其临床表现、内镜检查及影像学特征。早期鼻咽部坏死仅限于鼻咽部局部，组织缺损不明显，严重者可出现深部咽旁溃疡或基底区放射性骨坏死征象。患有放射性骨坏死和/或颈动脉暴露的患者死亡率很高。总之，放射后鼻咽坏死具有特征性的磁共振表现，与临床表现有较好的相关性，但病理检查对于诊断至关重要。
Postradiation nasopharyngeal necrosis is an important late effect of radiotherapy that affects prognosis in patients with nasopharyngeal carcinoma. In the present study, we reviewed the clinical and imaging features of 67 patients with pathologically diagnosed postradiation nasopharyngeal necrosis who were treated at Sun Yat-sen University Cancer Center between June 2006 and January 2010. Their clinical manifestations, endoscopic findings, and imaging features were analyzed. Early nasopharyngeal necrosis was limited to a local site in the nasopharyngeal region, and the tissue defect was not obvious, whereas deep parapharyngeal ulcer or signs of osteoradionecrosis in the basilar region was observed in serious cases. Those with osteoradionecrosis and/or exposed carotid artery had a high mortality. In conclusion, Postradiation nasopharyngeal necrosis has characteristic magnetic resonance imaging appearances, which associate well with clinical findings, but pathologic examination is essential to make the diagnosis.
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