Respiratory effects and arsenic contaminated well water in Bangladesh
Respiratory effects and arsenic contaminated well water in Bangladesh
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DOI：
10.1080/09603120220129346
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发表时间：
2002-06-01
影响因子：
3.2
通讯作者：
Rahman, M
中科院分区：
文献类型：
--
作者：
Milton, AH;Rahman, M
饮用水中的砷在孟加拉国引起广泛关注，该国大部分管井都受到污染。摄入砷会导致皮肤损伤，这被认为是明确的暴露。在孟加拉国进行了一项针对通过饮用水接触砷和未接触砷的受试者的呼吸系统影响的患病率比较研究。通过健康意识运动项目招募暴露的参与者。未暴露的参与者是随机选择的，其中管井未受到砷污染。共有 169 人参与（44 名暴露者表现出皮肤损伤；125 名未暴露者）。砷浓度范围为136至1000μl(-1)。还收集了有关呼吸系统体征和症状的信息，并且分析仅限于非吸烟者。慢性支气管炎和慢性咳嗽的粗患病率为2.1（95% CI 0.7-6.1）。慢性支气管炎患病率随着暴露量的增加而增加，以未暴露者为参考，分别为1.0、1.6、2.7和2.6。使用相同的未暴露人群作为参考，暴露类别的慢性咳嗽患病率分别为 1.0、1.6、2.7 和 2.6。剂量反应趋势相同（P
Arsenic in drinking water causes a widespread concern in Bangladesh, where a major proportion of tube wells is contaminated. Arsenic ingestion causes skin lesions, which is considered as definite exposure. A prevalence comparison study of respiratory effects among subjects with and without arsenic exposure through drinking water was conducted in Bangladesh. Exposed participants were recruited through health awareness campaign programs. Unexposed participants were randomly selected, where tubewells were not contaminated with arsenic. A total of 169 individuals participated (44 exposed individuals exhibiting skin lesions; 125 unexposed individuals). The arsenic concentrations ranged from 136 to 1000 mug l(-1). The information regarding respiratory system signs and symptoms were also collected and the analyses were confined to nonsmokers. The crude prevalence ratio for chronic bronchitis and chronic cough amounted to 2.1 (95% CI 0.7-6.1). The prevalence ratios for chronic bronchitis increased with increasing exposure, i.e., 1.0, 1.6, 2.7 and 2.6 using unexposed as the reference. The prevalence ratios for chronic cough were 1.0, 1.6, 2.7 and 2.6 for the exposure categories, using the same unexposed as the reference. The dose-response trend was the same (P