Bone changes after alcohol abuse.
Bone changes after alcohol abuse.
复制标题
酗酒后骨骼发生变化。
DOI：
--
复制
发表时间：
1984
期刊：
影响因子：
--
通讯作者：
L. Solomon
中科院分区：
文献类型：
--
作者：
C. Schnitzler;L. Solomon
在这项研究中，将 19 名重度或中度饮酒者的骨形态测量结果与 43 名不饮酒者（22 名患有骨关节炎 (OA) 的非骨质疏松患者和 21 名患有股骨颈骨折 (FNF) 的骨质疏松患者）的骨形态测量结果进行了比较。对髂骨活检标本进行了检查，通过定量组织形态测量法评估小梁骨体积和厚度、骨吸收和形成、类骨缝长度和宽度以及矿化前沿，与 22 名不饮酒的 OA 患者相比，饮酒组的骨小梁体积和厚度显着减少（P 分别小于 0.005 和 P 小于 0.0001），饮酒者的骨形成显着低于 OA 组（P 小于 0.0005），并且饮酒者的骨吸收显着高于 OA 组（P 小于 0.005）和 OA 组。 FNF（P 小于 0.01）组的骨形成显着低于中度饮酒者（P 小于 0.05）。饮酒组的矿化前沿程度显着低于 OA（P 小于 0.005）和 FNF（P 小于 0.0005）组。骨样接缝长度和宽度在三组中没有显着影响。结论是，酗酒与：（i）骨吸收和骨形成脱钩；（ii）骨小梁体积和厚度减少；（iii）轻度矿化缺陷。
In this study bone morphometric findings in 19 heavy or moderate drinkers are compared with those in 43 non-drinkers (22 non-osteoporotic patients with osteo-arthritis (OA) and 21 osteoporotic patients with femoral neck fractures (FNFs). Transiliac bone biopsy specimens were examined for assessment of trabecular bone volume and thickness, bone resorption and formation, osteoid seam length and width and the mineralization front by quantitative histomorphometry and microradiography. Trabecular bone volume and thickness were significantly diminished in the drinking group when compared with those in the 22 non-drinking patients with OA (P less than 0,005 and P less than 0,0001 respectively). Bone formation was significantly lower in the drinkers than in the OA group (P less than 0,0005), and bone resorption was significantly greater in the drinkers than in the OA (P less than 0,005) and FNF (P less than 0,01) groups. In heavy drinkers bone formation was significantly lower (P less than 0,05) than in moderate drinkers. The extent of the mineralization front was significantly lower in the drinking group than in the OA (P less than 0,005) and FNF (P less than 0,0005) groups. Osteoid seam length and width did not differ in the three groups. The presence of abnormal liver function test results did not significantly affect any of the parameters. It is concluded that alcohol abuse is associated with: (i) uncoupling of bone resorption and bone formation; (ii) reduced trabecular bone volume and thickness; and (iii) a mild mineralization defect.