Interleukin 17 acts in synergy with B cell-activating factor to influence B cell biology and the pathophysiology of systemic lupus erythematosus (Retracted Article)
Interleukin 17 acts in synergy with B cell-activating factor to influence B cell biology and the pathophysiology of systemic lupus erythematosus (Retracted Article)
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DOI：
10.1038/ni.1741
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发表时间：
2009-07-01
影响因子：
30.5
通讯作者：
Bonnefoy-Berard, Nathalie
中科院分区：
文献类型：
--
作者：
Doreau, Agnes;Belot, Alexandre;Bonnefoy-Berard, Nathalie
研究表明白细胞介素17（IL - 17）参与自身免疫性疾病，尽管其对B细胞生物学的影响尚未明确。在此我们证明，IL - 17单独或与B细胞活化因子联合可控制人类B细胞的存活和增殖以及它们分化为分泌免疫球蛋白的细胞。这种作用主要通过核因子 - κB调节的转录因子Twist - 1介导。为了支持我们的观察结果的相关性以及IL - 17在B细胞生物学中的潜在参与，我们发现系统性红斑狼疮患者的血清中IL - 17浓度高于健康人，并且IL - 17的含量与系统性红斑狼疮的疾病严重程度相关。
Studies have suggested involvement of interleukin 17 (IL-17) in autoimmune diseases, although its effect on B cell biology has not been clearly established. Here we demonstrate that IL-17 alone or in combination with B cell-activating factor controlled the survival and proliferation of human B cells and their differentiation into immunoglobulin-secreting cells. This effect was mediated mainly through the nuclear factor-kappa B-regulated transcription factor Twist-1. In support of the relevance of our observations and the potential involvement of IL-17 in B cell biology, we found that the serum of patients with systemic lupus erythematosus had higher concentrations of IL-17 than did the serum of healthy people and that IL-17 abundance correlated with the disease severity of systemic lupus erythematosus.