Microbial flora variations in the respiratory tract of mice
Microbial flora variations in the respiratory tract of mice
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DOI：
10.1590/s0074-02761999000500027
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发表时间：
1999-09-01
影响因子：
2.8
通讯作者：
Nader-Macias, ME
中科院分区：
文献类型：
--
作者：
de Gutierrez, RC;de Nader, OM;Nader-Macias, ME
呼吸道中稳定的微生物系统是抵抗病原微生物的重要防御机制。这一系统的扰动可能使病原体得以建立。在生态环境中，如呼吸道，有许多不同的因素在建立土著植物群中发挥作用。本文研究了小鼠呼吸道不同部位的正常微生物植物群及其自出生后的演变。我们的兴趣是要知道，这是在每个区域的微生物的优势群体，这是第一个能够殖民化，并随着时间的推移占主导地位，被用作益生菌microorganism.Our的结果表明，革兰氏阴性厌氧杆菌和严格的厌氧微生物是最晚出现在支气管，而需氧菌和革兰氏阳性球菌存在于呼吸道的所有领域。鼻道、咽部和气管中兼性需氧菌和严格厌氧菌数量相近，支气管中较少，优势菌为草绿色链球菌和红葡萄球菌，其次为链球菌。epidermidis、Lactobacillus和S. cohnii I，在每个研究日都存在，但比例不同。本文是以小鼠为实验模型研究土著植物群对病原体的保护作用的研究课题的第一部分。
A stable microbial system in the respiratory tract acts as an important defense mechanism against pathogenic microorganisms. Perturbations in this system may allow pathogens to establish. In an ecological environment such as the respiratory tract, there are many diverse factors that play a role in the establishment of the indigenous flora. In the present work we studied the normal microbial flora of different areas of the respiratory tract of mice and their evolution from the time the mice were born. Our interest was to know which were the dominant groups of microorganisms in each area, which were the first capable of colonizing and which dominated over time to be used as probiotic microorganisms.Our results show that Gram negative facultatively anaerobic bacilli and strict anaerobic microorganisms were the lat ones to appear in the bronchia, while aerobic and Gram positive cocci were present in all the areas of the respiratory tract. The number of facultative aerobes and strict anaerobes were similar in the nasal passage, pharynx instilled and trachea, but lowe in bronchia.The dominant species were Streptococcus viridans and Staphylococcus saprophyticcus, followed by S. epidermidis, Lactobacilli and S. cohnii I which were present on every studied days but at different proportions.This paper is the first part of a research topic investigating the protective effect of the indigenous flora against pathogens using the mice as an experimental model.