Hypertriglyceridemic waist and 7.5-year prospective risk of cardiovascular disease in asymptomatic middle-aged men
Hypertriglyceridemic waist and 7.5-year prospective risk of cardiovascular disease in asymptomatic middle-aged men
复制标题
DOI：
10.1038/sj.ijo.0803477
复制
发表时间：
2007-05-01
影响因子：
4.9
通讯作者：
Oppert, J-M
中科院分区：
文献类型：
--
作者：
Czernichow, S.;Bruckert, E.;Oppert, J-M
背景：很少有研究表明血浆甘油三酯(TG)和腰围(WC)的共同增加是心血管疾病(CVD)风险的有趣标志。目的：使用定义HTGW的临界值，我们在法国队列中研究了HTGW与CVD风险的前瞻性关联。设计：男性参与了SU.VI.MAX研究，这是一项旨在测试抗氧化剂补充对慢性病的影响的干预试验。数据收集于1994-1996年，对3430名男性进行了7.5年的随访。以WC>；=90 cm和TG>；=2 mmoL/L为界值，对两组人群心血管疾病的相对危险度(RR)(95%可信区间)进行评估。结果：低WC/低TG组占41.2%，高WC/低TG组占43.2%，低WC/高TG组占3.5%，HTGW组占12.1%。在随访期间，122名受试者发生了心血管事件。在这一组中，HTGW患病率为26.2%。调整年龄后，以低WC/低TG为参照组，HTGW组心血管疾病的RR(95%CI)与心血管疾病风险的相关性最高：2.13(1.21~3.76)。结论：在低风险中年男性人群中，HTGW与心血管疾病的风险相关。这一标记物可以作为一种有用的临床工具来筛查有心血管疾病风险的男性。
Background: Few studies suggest that the combined increase in plasma triglycerides (TG) and in waist circumference (WC), termed 'hypertriglyceridemic waist' (HTGW), is an interesting marker of risk for cardiovascular disease (CVD).Objective: Using cutoffs used for defining HTGW, we examined the prospective association of HTGW with CVD risk in a French cohort of men.Design: Men were participants in the SU.VI.MAX study, an intervention trial testing the impact of an antioxidant supplementation on chronic diseases. Data were collected in 1994-1996 in 3430 men followed up for 7.5 years. Cutoffs used for defining HTGW were WC >= 90 cm and TG >= 2 mmol/l. We assessed the relative risk (RR) (95% confidence interval (CI)) of CVD in groups defined according to both WC and TG levels.Results: In this population, 41.2% of the subjects were classified as low WC/low TG, 43.2% as high WC/low TG, 3.5% as low WC/high TG and 12.1% as HTGW. During follow-up, 122 subjects had a CVD event. In this group, HTGW prevalence was 26.2%. After adjustment for age, RR (95% CI) for CVD for the HTGW group showed the highest association with CVD risk: 2.13 (1.21-3.76), using low WC/low TG as the reference group.Conclusion: HTGW was associated with the risk of CVD after 7.5 years of follow-up in a low-risk middle-aged men population. This marker may be used as a useful clinical tool to screen for men at risk of CVD.