OXIDANTS IN CIGARETTE-SMOKE - RADICALS, HYDROGEN-PEROXIDE, PEROXYNITRATE, AND PEROXYNITRITE
OXIDANTS IN CIGARETTE-SMOKE - RADICALS, HYDROGEN-PEROXIDE, PEROXYNITRATE, AND PEROXYNITRITE
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DOI：
10.1111/j.1749-6632.1993.tb39148.x
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发表时间：
1993-05-28
期刊：
影响因子：
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通讯作者：
PACKER, L
中科院分区：
文献类型：
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作者：
PRYOR, WA;STONE, K;PACKER, L
本次会议的主题是营养素在预防吸烟相关疾病中的作用。正如本卷其他论文所评论的那样，吸烟者的血浆和/或肺灌洗液中抗氧化营养素（例如维生素 C 和 E）的水平较低。其他论文还评论了抗氧化营养素对与吸烟相关的疾病（例如心血管疾病、癌症和肺气肿）提供一定保护的证据。本文的目的是回顾香烟烟雾和香烟焦油中氧化剂的性质以及这些氧化剂的形成机制。我们认为，吸烟不仅会给肺部带来氧化负担，还会给吸烟者的整个机体带来氧化负担。本文提出了为什么抗氧化营养素可能在保护吸烟者免受吸烟的某些（但不幸的是，不是全部）病理后果方面发挥重要作用的机制见解。
The subject of this conference is the role of nutrients in preventing smokingrelated diseases. As reviewed by other papers in this volume, smokers have lower plasma and/or pulmonary lavage levels of antioxidant nutrients such as vitamins C and E. Other papers also review the evidence that antioxidant nutrients provide some protection against diseases associated with smoking (such as cardiovascular disease, cancer, and emphysema).It is the purpose of this paper to review the nature of the oxidants in cigarette smoke and cigarette tar and the mechanisms by which these oxidants are formed. We believe that smoking places an oxidative burden not only on the lung, but also on the entire organism of the smoker. This paper presents mechanistic insights into why antioxidant nutrients might play an important role in protecting smokers against some (but, unfortunately, not all) of the pathological consequences of smoking.