Detection of allergic reactions during oral food challenge using noninvasive urinary prostaglandin D2 metabolites
Detection of allergic reactions during oral food challenge using noninvasive urinary prostaglandin D2 metabolites
复制标题
使用无创尿前列腺素 D2 代谢物检测口服食物挑战期间的过敏反应
DOI：
10.1111/cea.14006
复制
发表时间：
2021
期刊：
影响因子：
6.1
通讯作者：
Ohya Y.
中科院分区：
文献类型：
--
作者：
Inuzuka Y;Yamamoto-Hanada K;Nakamura T;Shimosawa T;Murata T;Ohya Y.
应用尿PGDM作为OFC的生物标志物可以通过预防OFC期间的严重过敏反应(如过敏反应)来提高FA诊断程序的安全性。对食物有急性过敏反应的儿童尿前列腺素D2代谢物(PDGM)水平升高在食物挑战结局不确定的儿童中尿前列腺素D2代谢物(PDGM)水平也高于非反应儿童。这些初步数据表明，尿PGDM可能是食物挑战的有用生物标志物。1 OFC阳性或阴性结果由经验丰富的医生根据客观的过敏症状判断，而不参考准确的生物标志物。总之，尿液PGDM是一种新的、非侵入性的生物标记物，用于检测即时的食物引起的过敏反应，包括轻微的过敏反应。[摘自文章]《临床与实验过敏》版权归Wiley-Blackwell所有，未经版权所有者明确书面许可，不得将其内容复制或通过电子邮件发送到多个网站或发布到列表服务器。但是，用户可以打印、下载或通过电子邮件发送文章供个人使用。这篇摘要可以删节。对复制品的准确性不作任何保证。用户应参考该材料的原始出版版本，以获取完整摘要。版权适用于所有摘要。
Applying urinary PGDM as a biomarker for OFC could improve the safety of the FA diagnostic procedure by preventing severe allergic reactions, such as anaphylaxis, during an OFC. Urinary prostaglandin D2 metabolite (PDGM) levels increased in children with acute allergic reactions to foods Urinary PGDM were also increased in children with indeterminate food challenge outcomes compared to non-reactors These preliminary data suggest that urinary PGDM might be a useful biomarker for food challenges To the Editor, Oral food challenge (OFC) is a gold standard diagnostic method for food allergy (FA). 1 Positive or negative OFC results are judged by an experienced physician based on objective allergic signs without reference to accurate biomarkers. In summary, urinary PGDM is a novel, noninvasive biomarker for detecting immediate food-induced allergic reactions, including subtle allergic reactions.[Extracted from the article]Copyright of Clinical & Experimental Allergy is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. Copyright applies to all Abstracts.