Treatment of Cytomegalovirus Retinitis With Intraocular Sustained-Release Ganciclovir Implant-Reply
Treatment of Cytomegalovirus Retinitis With Intraocular Sustained-Release Ganciclovir Implant-Reply
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眼内缓释更昔洛韦植入剂治疗巨细胞病毒性视网膜炎
DOI：
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发表时间：
1995
期刊：
影响因子：
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通讯作者：
R. Nussenblatt
中科院分区：
文献类型：
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作者：
Daniel F. Martin;F. Ferris;N. Remaley;R. Nussenblatt
我们感谢弗里德伯格博士的来信和她提出的重要问题。在我们的研究中，39只接受植入物治疗的眼睛中有37只只有外周视网膜炎;两只眼睛有一些后极受累。20只眼睛的CMV累及视网膜小于10%，12只眼睛的视网膜累及率为10%至25%，7只眼睛的累及率超过25%。在发生视网膜脱离的眼睛中，2只受累小于10%，4只受累10%至25%，1只受累超过25%。在脱离时，CMV视网膜炎在所有病例中均不活跃。鉴于我们有限的样本量，不可能得出关于视网膜脱离风险的明确结论。虽然我们研究中的大多数患者的CMV病变相对较小，可能与视网膜脱离的风险较低有关，但几乎所有的病变都位于视网膜脱离的边缘。
In reply We thank Dr Friedberg for her letter and the important questions she raises. Thirty-seven of the 39 eyes treated with an implant in our study had only peripheral retinitis; two eyes had some involvement of the posterior pole. Twenty eyes had less than 10% of the retina involved by CMV, 12 eyes had 10% to 25% retinal involvement, and seven eyes had more than 25% involvement. Of the eyes that developed retinal detachment, two had less than 10% involvement, four had 10% to 25% involvement, and one had more than 25% involvement. At the time of detachment, the CMV retinitis was inactive in all cases. Given our limited sample size, definitive conclusions regarding the risk for retinal detachment are not possible. Although most patients in our study had relatively small CMV lesions that may be associated with a lower risk for retinal detachment, nearly all lesions were located