Ubiquitous expression of galectin-3 mRNA in benign and malignant thyroid tumors.
Ubiquitous expression of galectin-3 mRNA in benign and malignant thyroid tumors.
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Galectin-3 mRNA 在良性和恶性甲状腺肿瘤中普遍表达。
DOI：
10.1016/s0304-3835(03)00343-4
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发表时间：
2003
期刊：
影响因子：
9.7
通讯作者：
N. Amino
中科院分区：
文献类型：
--
作者：
T. Takano;A. Miyauchi;F. Matsuzuka;H. Yoshida;K. Kuma;N. Amino
我们检测了Galectin-3mRNA在正常甲状腺组织、甲状腺肿瘤组织和甲状腺成纤维细胞中的相对表达水平。Galectin-3mRNA在甲状腺良性肿瘤和恶性肿瘤中普遍表达。其在乳头状癌中的表达显著增加，但在滤泡性癌和腺瘤中的表达无显著差异。与以往用免疫组织化学方法分析Galectin-3蛋白表达的乐观报道不同，这些结果表明Galectin-3mRNA可能不是甲状腺癌分子诊断的合适靶点。
We measured the relative expression levels of galectin-3 mRNA to beta-actin mRNA in normal thyroid tissues, thyroid tumor tissues and thyroid-derived fibroblasts. Galectin-3 mRNA was expressed ubiquitously in both benign and malignant thyroid tumors. Although a significant increase in its expression was observed in papillary carcinomas, no significant difference was observed between follicular carcinomas and adenomas. In contrast to the previous optimistic reports using immunohistochemical analysis of the galectin-3 protein expression, these results demonstrate that galectin-3 mRNA may not be a suitable target for molecular-based diagnosis of thyroid carcinomas.