COMPARISON OF SERUM PLACENTAL PROTEIN HORMONE LEVELS IN DIABETIC AND NORMAL-PREGNANCY
COMPARISON OF SERUM PLACENTAL PROTEIN HORMONE LEVELS IN DIABETIC AND NORMAL-PREGNANCY
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DOI：
10.1210/jcem-68-1-3
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发表时间：
1989-01-01
影响因子：
5.8
通讯作者：
SIMPSON, JL
中科院分区：
文献类型：
--
作者：
BRAUNSTEIN, GD;MILLS, JL;SIMPSON, JL
关于糖尿病妇女妊娠期间母体血清胎盘激素浓度，存在明确数据。为了解决其中的一些差异，对参与NICHD-妊娠早期糖尿病研究的妇女进行了研究。在这项合作研究中，怀孕21天内确定的血清hCG测量。我们前瞻性地收集了35名胰岛素依赖型糖尿病妇女的185份血液样本和31名对照妇女的166份血液样本，均在妊娠5 - 37周之间。hCG的血清浓度，妊娠特异性β- 1-糖蛋白、胎盘催乳素和hCG α。连续测量。比较血清激素、空腹血糖、餐后1小时血糖和糖基化血红蛋白浓度之间的关系。血清hCG α在第一和第二孕期的多个时间点，糖尿病妇女中的hCG或妊娠特异性β-hCG水平显著低于对照妇女，而在hCG或妊娠特异性β-hCG的血清浓度中没有一致的差异。1-糖蛋白在妊娠糖尿病患者和对照组妇女之间存在差异。妊娠9-10周和20周的糖尿病妇女血清胎盘催乳素水平显著降低。糖尿病妇女的空腹血糖、餐后1小时血糖或糖化血红蛋白与任何胎盘蛋白水平之间均无相关性。这些数据与hCG α的合成和/或分泌缺陷一致。在需要胰岛素的糖尿病妇女怀孕的前两个三个月期间由细胞滋养层。
Conflicting data exist concerning maternal serum concentratins of placental hormones during pregnancy in women with diabetes mellitus. To resolve some of these discrepancies, women participating in the NICHD-Diabetes in Early Pregnancy Study were studied. In this collaborative study, pregnancy was identified within 21 days of conception by serum hCG measurements. We prospectivley collected 185 blood samples from 35 insulin-dependent diabetic women and 166 blood samples from 31 control women, all between 5 and 37 weeks gestation. Serum concentrations of hCG, pregnancy-specific .beta.-1-glycoprotein, placental lactogen, and hCG.alpha. were measured serially. The relationship between serum hormone, fasting blood glucose, 1-h postprandial blood glucose, and glycosylated hemoglobin concentrations was compared. Serum hCG.alpha. levels were significantly lower in the diabetic women than in control women at multiple time points during the first and second trimesters, while no consistent differences in the serum concentrations of hCG or pregnancy-specific .beta.-1-glycoprotein were found between pregnant diabetic and control women. Serum placental lactogen levels were significantly lower in diabetic women at 9-10 weeks and 20 weeks gestation. There were no correlations between fasting blood glucose, 1-h post-prandial blood glucose, or glycosylated hemoglobin and any of the placental protein levels in the diabetic women. These data are consistent with a defect in synthesis and/or secretion of hCG.alpha. by the cytotrophoblast during the first two trimesters of pregnancy in insulin-requiring diabetic women.