Effector T Helper Cell Subsets in Inflammatory Bowel Diseases.
Effector T Helper Cell Subsets in Inflammatory Bowel Diseases.
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DOI：
10.3389/fimmu.2018.01212
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发表时间：
2018
影响因子：
7.3
通讯作者：
Olson MR
中科院分区：
文献类型：
--
作者：
Imam T;Park S;Kaplan MH;Olson MR
胃肠道是高度免疫挑战的部位，因为它必须在耐受管腔内容物和产生针对病原体的免疫应答之间保持微妙的平衡。CD4+ T细胞是介导宿主保护性和稳态应答的关键。然而，当这种平衡被扰乱时，CD4+ T细胞也被认为是炎症性肠病（IBD）的主要驱动因素。许多CD4+ T细胞亚群已被确定为慢性肠道炎症持续存在的参与者。在过去的几十年里，对Th细胞的每个亚群如何发挥作用的理解已经大大增加。与此同时，这使得针对特定分子而不是广泛的免疫抑制剂的治疗创新得以发展。在这里，我们回顾了新出现的证据，每个子集的功能，促进和维持慢性炎症的特点，IBD。
The gastrointestinal tract is a site of high immune challenge, as it must maintain a delicate balance between tolerating luminal contents and generating an immune response toward pathogens. CD4+ T cells are key in mediating the host protective and homeostatic responses. Yet, CD4+ T cells are also known to be the main drivers of inflammatory bowel disease (IBD) when this balance is perturbed. Many subsets of CD4+ T cells have been identified as players in perpetuating chronic intestinal inflammation. Over the last few decades, understanding of how each subset of Th cells plays a role has dramatically increased. Simultaneously, this has allowed development of therapeutic innovation targeting specific molecules rather than broad immunosuppressive agents. Here, we review the emerging evidence of how each subset functions in promoting and sustaining the chronic inflammation that characterizes IBD.