Immunogenic Cell Death in Cancer Therapy.
Immunogenic Cell Death in Cancer Therapy.
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DOI：
10.32607/actanaturae.11523
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发表时间：
2022-01
期刊：
影响因子：
2
通讯作者：
Koval, Olga A.
中科院分区：
文献类型：
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作者：
Troitskaya, Olga S.;Novak, Diana D.;Richter, Vladimir A.;Koval, Olga A.
关键词：
细胞凋亡在化疗诱导的细胞死亡中起着至关重要的作用。认为细胞凋亡需要免疫沉默的传统理论最近得到了修正，免疫原性细胞死亡（ICD）的概念已经提出。本文综述了ICD诱导的主要特点。这些ICD标记物对于抗癌治疗的有效性以及细胞死亡调节的基础研究都很重要。已经充分描述了经历ICD的垂死癌细胞的“疫苗接种效应”的机制，包括在由相同的活肿瘤细胞再激发后激活特异性抗肿瘤应答。这篇综述还讨论了一整套的分子事件归因于细胞死亡的免疫原性类型：暴露的钙网蛋白和热休克蛋白HSP70的细胞膜的外表面和释放的核蛋白HMGB1和ATP到细胞外空间。ICD诱导剂的各种性质（化疗药物，细胞毒性蛋白，和溶瘤病毒），以及物理方法，在当前的审查进行了分类。
Apoptosis plays a crucial role in chemotherapy-induced cell death. The conventional theory holding that apoptosis needs to be immunologically silent has recently been revised, and the concept of immunogenic cell death (ICD) has been proposed. This review describes the main features of ICD induction. These ICD markers are important for the effectiveness of anticancer therapy, as well as for basic research into cell death regulation. The mechanism of the "vaccination effect" of dying cancer cells undergoing ICD has been fully described, including the activation of specific antitumor response after re-challenge by the same living tumor cells. This review also discusses the whole set of molecular events attributing cell death to immunogenic type: the exposure of calreticulin and the heat shock protein HSP70 to the outer surface of the cell membrane and the release of the nuclear protein HMGB1 and ATP into the extracellular space. ICD inducers of various nature (chemotherapy drugs, cytotoxic proteins, and oncolytic viruses), as well as physical methods, are classified in the current review.
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影响因子：
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作者：
Eike LM;Yang N;Rekdal Ø;Sveinbjørnsson B
通讯作者：
Sveinbjørnsson B
DOI：
10.1084/jem.20050915
发表时间：
2005-12-19
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Casares N;Pequignot MO;Tesniere A;Ghiringhelli F;Roux S;Chaput N;Schmitt E;Hamai A;Hervas-Stubbs S;Obeid M;Coutant F;Métivier D;Pichard E;Aucouturier P;Pierron G;Garrido C;Zitvogel L;Kroemer G
通讯作者：
Kroemer G
影响因子：
11.2
作者：
Diaconu, Iulia;Cerullo, Vincenzo;Hemminki, Akseli
通讯作者：
Hemminki, Akseli
影响因子：
8.8
作者：
Conway GE;Casey A;Milosavljevic V;Liu Y;Howe O;Cullen PJ;Curtin JF
通讯作者：
Curtin JF
影响因子：
64.8
作者：
通讯作者：
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