Effects of 17β-Estradiol and Bisphenol A on the Formation of Reproductive Organs in Planarians
Effects of 17β-Estradiol and Bisphenol A on the Formation of Reproductive Organs in Planarians
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DOI：
10.1086/bblv220n1p47
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发表时间：
2011-02-01
影响因子：
1.6
通讯作者：
Matsumoto, Midori
中科院分区：
文献类型：
--
作者：
Miyashita, Hitoshi;Nakagawa, Haruka;Matsumoto, Midori
涡虫在消融后具有非凡的再生能力，它们通过裂变进行无性繁殖。然而，一些涡虫也可以繁殖和维持其性器官。在再生过程中，他们现有的性器官退化，新的性器官发育。然而，人们对涡虫生殖器官发育过程中的激素调节知之甚少。在这项研究中，我们研究了 17 β-雌二醇（一种类固醇）和双酚 A（一种内分泌干扰物）对雌雄同体涡虫琉球涡虫性器官形成的影响。在控制条件下，所有蠕虫组织在消融后4周内再生为具有性器官的有性涡虫。然而，在双酚A或17β-雌二醇存在的情况下，尽管它们明显再生为有性涡虫，但雌性性器官之一的卵黄腺甚至在消融后7周也未能再生。这些数据表明涡虫具有类固醇激素系统，该系统在性器官的形成和成熟中起着关键作用。
Planarians have a remarkable capacity for regeneration after ablation, and they reproduce asexually by fission. However, some planarians can also reproduce and maintain their sexual organs. During the regenerative process, their existing sexual organs degenerate and new ones develop. However, little is known about hormonal regulation during the development of reproductive organs in planarians. In this study, we investigated the effects of 17 beta-estradiol (a steroid) and bisphenol A (an endocrine disrupter) on the formation of sexual organs in the hermaphroditic planarian Dugesia ryukyuensis. Under control conditions, all worm tissues regenerated into sexual planarians with sexual organs within 4 weeks after ablation. However, in the presence of bisphenol A or 17 beta-estradiol, although they apparently regenerated into sexual planarians, the yolk glands, which are one of the female sexual organs, failed to regenerate even 7 weeks after ablation. These data suggest that planarians have a steroid hormone system, which plays a key role in the formation and maturation of sexual organs.