THE ACTIONS OF 2 MONOAMINES ON SPINAL MOTONEURONS FROM STIMULATION OF THE LOCUS COERULEUS IN THE CAT
THE ACTIONS OF 2 MONOAMINES ON SPINAL MOTONEURONS FROM STIMULATION OF THE LOCUS COERULEUS IN THE CAT
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DOI：
10.1016/0006-8993(89)90369-7
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发表时间：
1989-04-10
期刊：
影响因子：
2.9
通讯作者：
BARNES, CD
中科院分区：
文献类型：
--
作者：
LAI, YY;STRAHLENDORF, HK;BARNES, CD
本研究调查了两种假定的胺递质（去甲肾上腺素和血清素）在介导蓝斑（LC）刺激后对未麻醉去大脑猫后肢屈肌和伸肌单突触反射（MSR）的促进作用中的作用。当以任一顺序顺序施用时，观察到美西麦角（一种5-羟色胺能阻滞剂）和哌唑嗪（一种α1-肾上腺素能阻滞剂）通过LC中施加的刺激引起腓肠肌-比目鱼肌和腓总肌MSR的增强的次总的递减变化。这些变化被确定为独立于胺能阻滞剂引起的血压变化。这些结果支持这样的假设：通过刺激LC来促进猫脊髓中的Ia组反射传递部分地由α1-去甲肾上腺素能和5-羟色胺能机制介导。
The present study investigates the role of the two putative amine transmitters (norepinephrine and serotonin) in mediating the facilitatory action following locus coeruleus (LC) stimulation on hindlimb flexor and extensor monosynaptic reflexes (MSRs) in unanesthetized, decerebrate cats. When administered sequentially, in either order, methysergide (a serotonergic blocker) and prazosin (an .alpha.1-adrenergic blocker) were observed to cause subtotal, decremental changes in the potentiation of gastrocneumius-soleus and common peroneal MSRs by stimuli applied in the LC. These changes were determined to be independent of the blood pressure changes induced by the aminergic blockers. These results support the hypothesis that the facilitation of the group Ia reflex transmission in cat spinal cord by stimulation of LC is mediated in part by .alpha.1-noradrenergic and serotonergic mechanisms.