BURSTS AND RECURRENCES OF BURSTS IN THE SPIKE TRAINS OF SPONTANEOUSLY ACTIVE STRIATE CORTEX NEURONS
BURSTS AND RECURRENCES OF BURSTS IN THE SPIKE TRAINS OF SPONTANEOUSLY ACTIVE STRIATE CORTEX NEURONS
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DOI：
10.1152/jn.1985.53.4.926
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发表时间：
1985-01-01
影响因子：
2.5
通讯作者：
SALCMAN, M
中科院分区：
文献类型：
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作者：
LEGENDY, CR;SALCMAN, M
通过长期植入电极，对未麻醉猫的纹状皮层中自发活动的单个单位的小集合（2-7）进行同步记录。记录的尖峰序列被计算机扫描，寻找尖峰脉冲，并对这些脉冲进行编目和研究。神经元的放电频率范围为0.16 - 32 spikes/s;平均值为8.9 spikes/s，标准差为7.0 spikes/s。尖峰脉冲的爆发被分配了一个定量测量，称为泊松惊喜（S），定义为它们在随机（泊松）尖峰序列中的概率的负对数。只有S大于10的爆发，对应于随机尖峰序列中约0.01爆发/1，000尖峰的发生率，被认为是感兴趣的。具有大于10的S的爆发以约5- 1 - 5个爆发/1，000个尖峰或约1-5个爆发/min的速率发生。速率随尖峰速率略微增加;对于具有3个尖峰/s的神经元，平均约2个爆发/min，对于具有30个尖峰/s的神经元，平均约4.5个爆发/min。大约21%的记录单位发出的脉冲明显少于其他单位（低于1脉冲/1,000个尖峰）。这些神经元的百分比是独立的锋电位率。爆发期间的尖峰频率被发现是平均尖峰频率的约3-6倍;对于较长的短爆发来说大致相同。爆发通常包含10-50个尖峰，持续0.5-2.0 s。当列出连续发射的脉冲群中的尖峰数量时，发现在某些神经元中，这些数量不是随机分布的，而是聚集在一个或多个优选值周围。从这个意义上说，爆发偶尔会在几分钟内“复发”几次。这一发现表明，神经元是高度可靠的。当两个或两个以上同时记录的神经元的爆发进行比较时，爆发往往出现时间接近，特别是在同一电极记录的神经元对之间;但爆发很少同时开始和结束在两个通道。一个神经元发出的重复爆发偶尔会伴随着其他神经元发出的定时重复爆发。
Simultaneous recordings were made from small collections (2-7) of spontaneously active single units in the striate cortex of unanesthetized cats, by means of chronically implanted electrodes. The recorded spike trains were computer scanned for bursts of spikes, and the bursts were catalogued and studied. The firing rates of the neurons ranged from 0.16 to 32 spikes/s; the mean was 8.9 spikes/s, the standard deviation 7.0 spikes/s. Bursts of spikes were assigned a quantitative measure, termed Poisson surprise (S), defined as the negative logarithm of their probability in a random (Poisson) spike train. Only bursts having S greater than 10, corresponding to an occurrence rate of about 0.01 bursts/1,000 spikes in a random spike train, were considered to be of interest. Bursts having S greater than 10 occurred at a rate of about 5-15 bursts/1,000 spikes, or about 1-5 bursts/min. The rate slightly increased with spike rate; averaging about 2 bursts/min for neurons having 3 spikes/s and about 4.5 bursts/min for neurons having 30 spikes/s. About 21% of the recorded units emitted significantly fewer bursts than the rest (below 1 burst/1,000 spikes). The percentage of these neurons was independent of spike rate. The spike rate during bursts was found to be about 3-6 times the average spike rate; about the same for longer as for shorter bursts. Bursts typically contained 10-50 spikes and lasted 0.5-2.0 s. When the number of spikes in the successively emitted bursts was listed, it was found that in some neurons these numbers were not distributed at random but were clustered around one or more preferred values. In this sense, bursts occasionally "recurred" a few times in a few minutes. The finding suggests that neurons are highly reliable. When bursts of two or more simultaneously recorded neurons were compared, the bursts often appeared to be temporally close, especially between pairs of neurons recorded by the same electrode; but bursts seldom started and ended simultaneously on two channels. Recurring bursts emitted by one neuron were occasionally accompanied by time-locked recurring bursts by other neurons.