Brain-derived neurotrophic factor (BDNF) Val66Met polymorphism in schizophrenia is associated with age at onset and symptoms
Brain-derived neurotrophic factor (BDNF) Val66Met polymorphism in schizophrenia is associated with age at onset and symptoms
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DOI：
10.1016/j.neulet.2006.02.054
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发表时间：
2006-06
影响因子：
2.5
通讯作者：
Shusuke Numata;S. Ueno;Jun‐ichi Iga;K. Yamauchi;H. Song;Koji Ohta;Sawako Kinouchi;Sumiko Shibuya‐Tayoshi;Shin'ya Tayoshi;Michitaka Aono;Naomi Kameoka;Satsuki Sumitani;M. Tomotake;Y. Kaneda;T. Taniguchi;Yasuhito Ishimoto;T. Ohmori
中科院分区：
文献类型：
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作者：
Shusuke Numata;S. Ueno;Jun‐ichi Iga;K. Yamauchi;H. Song;Koji Ohta;Sawako Kinouchi;Sumiko Shibuya‐Tayoshi;Shin'ya Tayoshi;Michitaka Aono;Naomi Kameoka;Satsuki Sumitani;M. Tomotake;Y. Kaneda;T. Taniguchi;Yasuhito Ishimoto;T. Ohmori
脑源性神经营养因子(BDNF)是一种神经营养因子，能促进神经元的多种功能，调节神经传递。已有研究表明，精神分裂症患者脑组织中存在脑源性神经营养因子水平的改变，而脑源性神经营养因子基因表达的改变可能与精神分裂症的发病有关。最近的研究表明，BDNF基因的一种变异(Val66Met多态性)会影响神经元的功能，并与多种神经和精神疾病有关。以DSM-IV诊断的159例慢性精神分裂症患者为研究对象，探讨BDNF Val66Met基因多态性与发病年龄及临床症状严重程度的关系。BDNFVal/Met、BDNFVal/Met和BDNFMet/Met的平均发病年龄分别为(27.5±9.5)岁、(25.5±7.4)岁和(22.9±6.0)岁，差异有统计学意义(P=0.023)。简明精神病评定量表平均得分在三组间差异有统计学意义(P=0.003)。阳性家族史与阴性家族史的BDNF基因分布比较，差异无统计学意义(P=0.21)。我们的研究表明，BDNF基因Val66Met的多态性与精神分裂症的发病年龄和长期抗精神病药物治疗后的临床症状水平有关。
Brain-derived neurotrophic factor (BDNF) is a neurotrophic factor that promotes several functions of neurons and modulates neurotransmissions. It has been reported that there are alterations of BDNF levels in schizophrenic brains and that BDNF gene expressional changes would be responsible for the etiology of schizophrenia. Recent studies have shown that a variation of BDNF gene (Val66Met polymorphism) affects the function of neurons, and is associated with several neurological and psychiatrical disorders. We investigated the relationship between BDNF Val66Met polymorphism and the onset age as well as levels of clinical symptoms in 159 of chronic schizophrenia in-patients diagnosed by DSM-IV. The mean onset ages were 27.5±9.5 for BDNF Val/Val, 25.5±7.4 for BDNF Val/Met and 22.9±6.0 for BDNF Met/Met and this polymorphism was significantly associated with age at onset (P=0.023). The mean Brief Psychiatric Rating Scale scores (BPRS) were significantly different among those three groups (P=0.003). No significant differences were demonstrated comparing the BDNF genotype distributions of positive and negative family history (P=0.21). Our investigation indicates that the BDNF gene Val66Met polymorphism is related to the onset age of schizophrenia and the levels of clinical symptoms that remain after long-term antipsychotic treatment.