PREDICTORS OF LOCAL CONTROL AFTER SINGLE-DOSE STEREOTACTIC IMAGE-GUIDED INTENSITY-MODULATED RADIOTHERAPY FOR EXTRACRANIAL METASTASES
PREDICTORS OF LOCAL CONTROL AFTER SINGLE-DOSE STEREOTACTIC IMAGE-GUIDED INTENSITY-MODULATED RADIOTHERAPY FOR EXTRACRANIAL METASTASES
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DOI：
10.1016/j.ijrobp.2009.12.038
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发表时间：
2011-03-15
影响因子：
7
通讯作者：
Yamada, Yoshiya
中科院分区：
文献类型：
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作者：
Greco, Carlo;Zelefsky, Michael J.;Yamada, Yoshiya
目的：目的：报告单剂量图像引导调强放疗（SD-IGRT）治疗颅外转移灶后的肿瘤局部控制情况。方法：103例患者共126个转移灶接受SD-IGRT治疗，处方剂量为18-24戈伊结果：中位随访18个月（2-45个月），总的精算局部无复发生存率（LRFS）为64%。中位失败时间为9.6个月（范围：1-23个月）。在单变量分析中，LRFS与处方剂量显著相关（p = 0.029）。按剂量分层为高（23至24戈伊）、中（21至22戈伊）和低（18至20戈伊）剂量水平，显示高剂量（82%）和低剂量（25%）之间的LRFS差异非常显著（p < 0.0001）。总体而言，组织学对LRFS无显著影响（p = 0.16）。肾细胞组织学显示出深刻的剂量反应效应，在高剂量水平（23至24戈伊）下的LRFS为80%，而在低剂量（22戈伊）下的LRFS为37%。（C）2011 Elsevier Inc.
Purpose: To report tumor local control after treatment with single-dose image-guided intensity-modulated radiotherapy (SD-IGRT) to extracranial metastatic sites.Methods and Materials: A total of 126 metastases in 103 patients were treated with SD-IGRT to prescription doses of 18-24 Gy (median, 24 Cy) between 2004 and 2007.Results: The overall actuarial local relapse free survival (LRFS) rate was 64% at a median follow-up of 18 months (range, 2-45 months). The median time to failure was 9.6 months (range, 1-23 months). On univariate analysis, LRFS was significantly correlated with prescription dose (p = 0.029). Stratification by dose into high (23 to 24 Gy), intermediate (21 to 22 Gy), and low (18 to 20 Gy) dose levels revealed highly significant differences in LRFS between high (82%) and low doses (25%) (p < 0.0001). Overall, histology had no significant effect on LRFS (p = 0.16). Renal cell histology displayed a profound dose response effect, with 80% LRFS at the high dose level (23 to 24 Gy) vs. 37% with low doses ( 22 Gy) of radiation are delivered. (C)2011 Elsevier Inc.