Serum levels of anticholinergic drugs and impaired recent memory in chronic schizophrenic patients.
Serum levels of anticholinergic drugs and impaired recent memory in chronic schizophrenic patients.
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慢性精神分裂症患者抗胆碱能药物的血清水平和近期记忆受损。
DOI：
10.1176/ajp.139.11.1460
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发表时间：
1982
期刊：
影响因子：
--
通讯作者：
Coyle,JT
中科院分区：
文献类型：
--
作者：
Tune,LE;Strauss,ME;Lew,MF;Breitlinger,E;Coyle,JT
作者测试了24名稳定的精神分裂症门诊患者的工作记忆或近期记忆，这些患者正在服用精神药物。记忆表现与精神分裂症症状的严重程度，言语智商，或血清抗精神病药物水平，但有一个显着的负相关血清抗胆碱能水平和记忆任务的性能。结果表明，治疗剂量的抗胆碱能药物可能会导致认知功能的微妙损害。
The authors tested working or recent memory in 24 stabilized schizophrenic outpatients who were taking psychotropic medication. Memory performance did not correlate with severity of schizophrenic symptoms, verbal IQ, or serum neuroleptic levels, but there was a significant inverse correlation between serum anticholinergic levels and performance on the memory task. The results suggest that therapeutic doses of anticholinergics may cause subtle impairments of cognitive functions.