SNAP-23 is located in the basolateral plasma membrane of rat pancreatic acinar cells
SNAP-23 is located in the basolateral plasma membrane of rat pancreatic acinar cells
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DOI：
10.1016/s0014-5793(97)01013-2
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发表时间：
1997-09-08
期刊：
影响因子：
3.5
通讯作者：
Trimble, WS
中科院分区：
文献类型：
--
作者：
Gaisano, HY;Sheu, L;Trimble, WS
SNARE假说认为，胞吐作用的特异性是由囊泡(v-)陷阱和靶膜(t-)陷阱之间的适当相互作用调节的。我们在这里显示胰腺腺泡细胞表达SNAP-25t-SNARE同系物SNAP-23，并发现这种t-SNARE高度集中在基底外侧质膜上，而在同一组织中的内分泌胰岛表达低于可检测到的水平。这是SNAP-23在极化组织中的首次定位，表明这种t型圈套可能与Synaxin-4相互作用，介导基底外侧分泌。(C)1997年欧洲生化学会联合会。
The SNARE hypothesis proposes that specificity of exocytosis is regulated by the appropriate interactions between the vesicle (v-) SNARE and the target membrane (t-) SNAREs. We show here that pancreatic acinar cells express the SNAP-25 t-SNARE homolog SNAP-23, and find that this t-SNARE is most highly concentrated on the basolateral plasma membrane while being expressed below detectable levels iu endocrine islets within the same tissue. This is the first localization of SNAP-23 within a polarized tissue and suggests that this t-SNAREs may interact with syntaxin-4 to mediate basolateral secretion. (C) 1997 Federation of European Biochemical Societies.