Regional homogeneity of intrinsic brain activity correlates with auditory-motor processing of vocal pitch errors
Regional homogeneity of intrinsic brain activity correlates with auditory-motor processing of vocal pitch errors
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内在大脑活动的区域同质性与音高错误的听觉运动处理相关
DOI：
10.1016/j.neuroimage.2016.08.005
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发表时间：
2016-11-15
期刊：
影响因子：
5.7
通讯作者：
Liu, Hanjun
中科院分区：
文献类型：
--
作者：
Guo, Zhiqiang;Huang, Xiyan;Liu, Hanjun
有充分的证据表明，说话者会对他们在听觉反馈中感知到的错误进行快速的补偿性声音调整。然而，它们在补偿感知到的错误的程度上存在很大差异，这一事实却很少受到关注。本研究调查了休息时的内在大脑活动是否可以预测个体在发声过程中补偿音高偏移的听觉反馈的行为和皮层反应。通过将静息状态fMRI信号的区域均匀性（ReHo）与-200美分和-500美分音调变化的声音补偿和事件相关电位（N1和P2）相关联，研究了这种关系。在行为上，声音补偿的大小与200美分和-500美分时的右侧辅助运动区（SMA）、-200美分时的右侧初级运动皮层（M1）和-500美分时的左侧运动前皮层（PMC）的ReHo值显著相关。对于两种音调偏移大小，左侧额下回（IFG）、右侧颞上回（STG）、双侧M1和左侧SMA的ReHo和N1振幅之间存在显著相关性。在-200和-500美分时，双侧IFG、右侧STG、左侧SMA和M1、左侧PMC为-200美分，右侧SMA为-500美分时，ReHo和P2振幅之间存在显著相关性。这些发现提供了第一个证据，表明大脑内在活动的区域同质性可以预测行为和皮层反应，以补偿声音听觉反馈中的音高误差。(C) 2016 Elsevier Inc.版权所有。
It has been well documented that speakers produce rapid compensatory vocal adjustments for errors they perceive in their auditory feedback. The fact that they differ greatly in the degree to which they compensate for perceived errors, however, has received much less attention. The present study investigated whether intrinsic brain activity during resting can predict an individual's behavioral and cortical responses in compensating for pitch-shifted auditory feedback during vocalization. This relationship was investigated by correlating the regional homogeneity (ReHo) of resting-state fMRI signals with the vocal compensation and event-related potentials (N1 and P2) in response to pitch shifts of -200 and -500 cents. Behaviorally, themagnitudes of vocal compensation were significantly correlated with the ReHo values in the right supplementary motor area (SMA) for both-200 and -500 cents, the right primary motor cortex (M1) for -200 cents, and the left premotor cortex (PMC) for -500 cents. For both pitch shift sizes, there were significant correlations between ReHo and N1 amplitude in the left inferior frontal gyrus (IFG), right superior temporal gyrus (STG), bilateral M1, and left SMA. Significant correlations between ReHo and P2 amplitude were observed in the bilateral IFG, right STG, left SMA and M1 for -200 and -500 cents, the left PMC for -200 cents, and the right SMA for -500 cents. These findings provide the first evidence that regional homogeneity of intrinsic brain activity can predict behavioral and cortical responses in compensating for pitch errors in voice auditory feedback. (C) 2016 Elsevier Inc. All rights reserved.