Resolution of inflammation-induced axonal mechanical sensitivity and conduction slowing in C-fiber nociceptors
Resolution of inflammation-induced axonal mechanical sensitivity and conduction slowing in C-fiber nociceptors
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DOI：
10.1016/j.jpain.2007.10.012
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发表时间：
2008-02-01
期刊：
影响因子：
4
通讯作者：
Bove, Geoffrey M.
中科院分区：
文献类型：
--
作者：
Dilley, Andrew;Bove, Geoffrey M.
本研究是在体内调查的时间过程中炎症诱导的轴突机械敏感性（AMS）在完整的C-纤维轴突。在大鼠坐骨神经中诱导局部神经炎后，AMS在1周（18.2%）和4周（11.6%）在C纤维轴突中发展。到8周时，AMS几乎不存在（2.1%）。还在L4脊神经横断后的完整L5神经元中测试AMS，其在坐骨神经内诱导弥漫性炎症。1周时，10%的神经元发生AMS。在未手术动物中未观察到AMS。局限性神经炎也引起L5背根传导速度（CV）的变化。US在1周（-7.7%）和4周（-17.6%）时下降，并在8周时恢复正常。L4横断同样减少了L5背根轴突的Us（-13.7%）。在任何组中，持续活动的比例或比率均无显著变化。这些结果表明，轴突的变化，由于神经炎是不是永久性的。因此，在持续性运动诱发的放射性肢体疼痛患者中，几乎没有临床上明显的神经损伤迹象，可能存在影响神经的持续性炎性病变。神经炎症或神经炎，引起轴突机械敏感性，这是运动引起的放射性肢体疼痛的神经基质。本研究检测了诱导轴突机械敏感性和传导速度变化的时间过程，神经炎症后完整的C纤维轴突。结果表明，减少神经炎症的治疗可能对放射性疼痛患者有益。(c)2008年，美国疼痛协会。
The present study is an in vivo investigation into the time course of inflammation-induced axonal mechanical sensitivity (AMS) in intact C-fiber axons. After induction of a localized neuritis in the rat sciatic nerve, AMS developed in C-fiber axons at 1 (18.2%) and 4 weeks (11.6%). By 8 weeks, AMS was virtually absent (2.1%). AMS was also tested in intact L5 neurons after L4 spinal nerve transection, which induces a diffuse inflammation within the sciatic nerve. At 1 week, AMS developed in 10% of neurons. No AMS was observed in unoperated animals. The localized neuritis also caused changes in L5 dorsal root conduction velocities (CVs). Us decreased at 1 week (-7.7%) and 4 weeks (-17.6%) and returned to normal by 8 weeks. L4 transection similarly reduced Us (-13.7%) of L5 dorsal root axons. There were no significant changes among any groups in the proportion or rate of ongoing activity. These results demonstrate that the axonal changes due to neuritis are not permanent. Therefore, in patients with persistent movement-induced radiating limb pain with few clinically apparent signs of nerve damage, there may be a persisting inflammatory lesion affecting the nerve.Perspective: Nerve inflammation, or neuritis, causes axonal mechanical sensitivity, which is the neural substrate for radiating limb pain induced by movement This study examined the time course of induced axonal mechanical sensitivity and conduction velocity changes in intact C-fiber axons after nerve inflammation. The results suggest that treatment to reduce nerve inflammation may be beneficial to patients with radiating pain. (c) 2008 by the American Pain Society.