Role of taurine in feeding the low-birth-weight infant.
Role of taurine in feeding the low-birth-weight infant.
复制标题
牛磺酸在喂养低出生体重婴儿中的作用。
DOI：
10.1016/s0022-3476(84)80503-x
复制
发表时间：
1984
期刊：
影响因子：
--
通讯作者：
Heird,WC
中科院分区：
文献类型：
--
作者：
Okamoto,E;Rassin,DK;Zucker,CL;Salen,GS;Heird,WC
以乳清为主的奶粉配方奶粉或添加牛磺酸的配方奶粉(45μ/kg/d)喂养适合胎龄的低出生体重儿，测定其血浆和尿牛磺酸浓度、生长发育、氮平衡、十二指肠胆盐浓度和模式、粪便胆汁酸排泄量和肠道脂肪吸收。两组患者的平均血浆牛磺酸浓度无差异。对照组和补充组的平均尿牛磺酸浓度分别为2.6 7±0.6 9和12.4 1±5.2 0μ/dl。然而，在研究期间，补充牛磺酸的婴儿的尿牛磺酸浓度显著下降。两组之间的生长和氮素保持都没有不同。十二指肠牛磺酸以及胆酸盐和鹅去氧胆酸盐的甘氨酸结合物的平均浓度在补充的婴儿中较高。十二指肠总胆盐浓度与牛磺酸排泄量呈正相关(r=0.71)；这种相关性加上补充组较低的十二指肠胆固醇浓度，表明补充组胆固醇转化为胆汁酸的能力更强。然而，对照组和补充组婴儿的平均肠道脂肪吸收没有差别。
Plasma and urinary taurine concentrations, growth, nitrogen balance, duodenal bile salt concentrationand pattern, fecal bile acid excretion, and intestinal fat absorption were determined in appropriate for gestational age low-birth-weight infants fed either a whey-predominant cow milk formula or the same formula supplemented with taurine (45 μmol/kg/day). Mean plasma taurine concentration in the two groups did not differ. Mean urinary taurine concentration in the control and supplemented groups over the entire study period were 2.67±0.69 and 12.41±5.20 μmol/dl, respectively (P<0.05). Urinary taurine concentration in the supplemented infants, however, decreased significantly during the study period. Neither growth nor nitrogen retention differed between the two groups. Mean duodenal concentrations of taurine as well as glycine conjugates of both cholate and chenodeoxycholate were higher in supplemented infants. Total duodenal bile salt concentration correlated positively with taurine status as reflected by urinary taurine excretion (r=0.71); this correlation plus the lower duodenal cholesterol concentration in supplemented infants suggests that conversion of cholesterol to bile acids was greater in supplemented infants. Mean intestinal fat absorption in control and supplemented infants, however, did not differ.