Visceral Adipose Tissue Volume Estimated at Imaging Sites 5-6 cm Above L4-L5 Is Optimal for Predicting Cardiovascular Risk Factors in Obese Japanese Men
Visceral Adipose Tissue Volume Estimated at Imaging Sites 5-6 cm Above L4-L5 Is Optimal for Predicting Cardiovascular Risk Factors in Obese Japanese Men
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DOI：
10.1620/tjem.227.297
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发表时间：
2012-08-01
影响因子：
2.2
通讯作者：
Tanaka, Kiyoji
中科院分区：
文献类型：
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作者：
So, Rina;Sasai, Hiroyuki;Tanaka, Kiyoji
内脏脂肪组织（VAT）与心血管疾病（CVD）之间的关系已被清楚地证明。虽然典型的增值区在第4和第5腰椎（L4-L5）被用来估计增值区体积，越来越多的证据表明，这个测量位置可能不是理想的。然而，这些发现对亚洲人的影响尚不清楚。因此，我们在肥胖的日本男性中寻找与心血管疾病危险因素相关的更好的VAT测量点。82名肥胖男性参与了一项横断面研究。在这些参与者中，37名男性完成了为期12周的干预（90分钟，每周3天），用于解决VAT测量部位与CVD危险因素之间的纵向关联。使用连续MRI图像（从L4-L5以下3 cm到L4-L5以上20 cm）来探索每个VAT区域与CVD危险因素（总胆固醇、HDL胆固醇、甘油三酯、葡萄糖、胰岛素和血压）之间的关系。位于L4-L5上方5- 9cm的图像与HDL胆固醇和甘油三酯有显著相关性，但L4-L5位点在横断面分析中没有显著相关性。在运动后，位于L4-L5上方5厘米的图像与总胆固醇（r = 0.46）和葡萄糖（r = 0.36）的变化相关性最高。此外，位于L4-L5上方6 cm的图像与甘油三酯（r = 0.37）和胰岛素（r = 0.37）的变化相关性最高。因此，与L4-L5的典型位置相比，位于L4-L5上方5-6厘米的VAT图像范围可能是识别CVD危险因素的最佳选择。
The association between visceral adipose tissue (VAT) with cardiovascular disease (CVD) has been clearly demonstrated. Although typical VAT area at 4th and 5th lumbar vertebrae (L4-L5) is used to approximate VAT volume, growing evidence has suggested that this measurement site may not be ideal. However, these findings for Asian people remain unclear. Thus, we searched for the better VAT measurement sites associated with CVD risk factors in obese, Japanese men. Eighty-two obese men were included in a cross-sectional study. Among these participants, 37 men completed the 12-week intervention (90 min and 3 d/week) were used for addressing longitudinal association between the VAT measurement sites and CVD risk factors. Consecutive MRI images (from 3 cm below L4-L5 to 20 cm above L4-L5) were used to explore the relationship between each VAT area and CVD risk factors (total cholesterol, HDL cholesterol, triglycerides, glucose, insulin and blood pressure). The images located only 5-9 cm above L4-L5 had significant correlations with HDL cholesterol and triglycerides, but L4-L5 site did not in the cross-sectional analysis. In response to exercise, the image located 5 cm above L4-L5 showed the highest correlations with changes in total cholesterol (r = 0.46) and glucose (r = 0.36). Also, the image located 6 cm above L4-L5 showed highest correlations with changes in triglycerides (r = 0.37) and insulin (r = 0.37). Thus, the range of VAT images located 5-6 cm above L4-L5 may be optimal for identifying CVD risk factors compared to a typical site of L4-L5.