CHELATE SYNTHESIS OF 3-ETHOXYCARBONYL-4-HYDROXY-2-TRIFLUOROMETHYLPYRIDINE FROM ETHYL ACETOACETATE AND TRIFLUOROACETONITRILE
CHELATE SYNTHESIS OF 3-ETHOXYCARBONYL-4-HYDROXY-2-TRIFLUOROMETHYLPYRIDINE FROM ETHYL ACETOACETATE AND TRIFLUOROACETONITRILE
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DOI：
10.1007/bf00700905
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发表时间：
1995-07-01
影响因子：
1.7
通讯作者：
BOGDANOV, VS
中科院分区：
文献类型：
--
作者：
DOROKHOV, VA;VASILEV, LS;BOGDANOV, VS
以乙酰乙酸乙酯为原料，在乙酰乙酸镍（Ni（acac））（2）存在下，与三氟乙腈反应合成了2-乙酰基-3-氨基-4，4，4-三氟-2-丁烯酸乙酯。前者的二苯硼螯合物与二甲基甲酰胺二甲缩醛缩合，然后在乙醇中回流，得到3-乙氧羰基-4-羟基-2-三氟甲基吡啶。
Ethyl 2-acetyl-3-amino-4,4,4-trifluoro-2-butenoate was synthesized by treatment of ethyl acetoacetate with CF3CN in the presence of Ni(acac)(2). Condensation of the diphenylboron chelate of the former with dimethylformamide dimethylacetal followed by refluxing in ethanol yielded 3-ethoxycarbonyl-4-hydroxy-2-trifluoromethylpyridine.