A fresh look at iontophoresis.
A fresh look at iontophoresis.
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DOI：
10.1001/archopht.1984.01040031483028
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发表时间：
1984-12
影响因子：
--
通讯作者：
L. Hughes;D. Maurice
中科院分区：
文献类型：
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作者：
L. Hughes;D. Maurice
通过1 mamp，荧光素和庆大霉素离子进入兔子前房的速率增加了100倍以上；离子电渗疗法比滴注更好地控制渗透的药物量。讨论了该手术的潜在价值、安全性和局限性，并为增加提供了理论基础。描述了在临床中使用离子电渗疗法的实用方法。对于具有完整上皮的眼睛，应用 30 秒应能在 12 小时内使眼前段的抗生素达到治疗水平。
The rate of penetration of fluorescein and gentamicin ions into the anterior chamber of the rabbit was increased more than 100-fold by the passage of 1 mamp; the amount of drug that penetrates is better controlled by iontophoresis than by instillation. The potential value, the safety and the limitations of this procedure are discussed, and a theoretical basis for the increase is provided. Practical methods of using iontophoresis in the clinic are described. A 30-s application should result in a therapeutic level of the antibiotic in the anterior segment over a 12-hour period in eyes with an intact epithelium.