Temporal and qualitative dynamics of conditioned taste aversion processing: Combined generalization testing and licking microstructure analysis
Temporal and qualitative dynamics of conditioned taste aversion processing: Combined generalization testing and licking microstructure analysis
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DOI：
10.1037/0735-7044.119.4.983
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发表时间：
2005-08-01
影响因子：
1.9
通讯作者：
Nguyen, EAN
中科院分区：
文献类型：
--
作者：
Baird, JP;John, SJS;Nguyen, EAN
舔微观结构的模式，在不同阶段的条件性味觉厌恶（CTA）进行了评价。在实验1中，大鼠摄入氯化锂（LiCl）进行3次试验，然后在3次试验中提供氯化钠（NaCl）或蔗糖。发展了对LiCl的CTA并将其推广到氯化钠，但没有推广到蔗糖。CTA摄入抑制的特征在于爆发大小、平均摄入率和爆发内舔率的减少，以及短暂停顿和爆发计数的增加。与以前的研究相比，在第一次获得试验结束时，氯化锂舔体从最初与通常接受的氯化钠相匹配的模式转变为与通常避免的盐酸奎宁相匹配的模式。在实验2中，开发了一种新的范例，以表明大鼠在其第一次LiCl访问的9分钟内表达CTA泛化。这些结果表明，舔微观结构分析可以用来分析由产生厌恶状态的处理引起的享乐评价的变化。
The pattern of licking microstructure, during various phases of a conditioned taste aversion (CTA) was evaluated. In Experiment 1, rats ingested lithium chloride (LiCl) for 3 trials and were then offered sodium chloride (NaCl) or sucrose on 3 trials. A CTA to LiCl developed and generalized to NaCl but not to sucrose. CTA intake suppression was characterized by reductions in burst size, average ingestion rate, and intraburst lick rate, and increases in brief pauses and burst counts. Compared with previous studies, LiCl licking shifted from a pattern initially matching that for normally accepted NaCl to one matching licking for normally avoided quinine hydrochloride by the end of the 1 st acquisition trial. In Experiment 2, a novel paradigm was developed to show that rats expressed CTA generalization within 9 min of their first LiCl access. These results suggest that licking microstructure analysis can be used to assay changes in hedonic evaluation caused by treatments that produce aversive states.