Kumada-Corriu coupling of Grignard reagents, probed with a chiral Grignard reagent
Kumada-Corriu coupling of Grignard reagents, probed with a chiral Grignard reagent
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DOI：
10.1039/b300033h
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发表时间：
2003-01-01
影响因子：
4.9
通讯作者：
Hoffmann, RW
中科院分区：
文献类型：
--
作者：
Hölzer, B;Hoffmann, RW
在Pd（0）或Ni（0）催化下，以含镁碳原子为唯一立体中心的格氏试剂2与溴乙烯偶联，得到构型完全保留的化合物3。使用Fe（acac）（3）或Co（acac）（2）作为催化剂的偶联伴随着相当大的外消旋化。这些研究结果进行了讨论相对于协调极性和逐步SET transmetabolism途径之间的二分法。
The Grignard reagent 2, in which the magnesium-bearing carbon atom is the sole stereogenic centre has been coupled with vinyl bromide under Pd(0) or Ni(0)-catalysis to give compound 3 with full retention of configuration. Coupling using Fe(acac)(3) or Co(acac)(2) as catalyst was accompanied by considerable racemisation. These findings are discussed with respect to a dichotomy between concerted polar and stepwise SET transmetallation pathways.