Adherent cell function in murine T-lymphocyte antigen recognition. IV. Enhancement of murine T-cell antigen recognition by human leukocytic pyrogen.
Adherent cell function in murine T-lymphocyte antigen recognition. IV. Enhancement of murine T-cell antigen recognition by human leukocytic pyrogen.
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DOI：
10.1084/jem.150.3.709
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发表时间：
1979-09-19
期刊：
影响因子：
--
通讯作者：
Rosenthal AS
中科院分区：
文献类型：
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作者：
Rosenwasser LJ;Dinarello CA;Rosenthal AS
利用巨噬细胞依赖性、抗原特异性的小鼠T细胞增殖实验来检测小鼠和人类贴壁细胞的可溶性产物在T淋巴细胞活化中的作用。高纯度的人白细胞热原，以及小鼠和人单核吞噬细胞-巨噬细胞的上清液刺激免疫t细胞对多决定因素抗原二硝基苯-卵清蛋白和锁眼帽贝血青素的增殖反应。讨论了这些研究的意义以及白细胞热原与人淋巴细胞活化因子的关系。
A macrophage-dependent, antigen-specific murine T-cell proliferation assay was utilized to examine the role of soluble products of murine and human adherent cells in the activation of T lymphocytes. Highly purified human leukocytic pyrogen, and supernates from both murine and human mononuclear phagocytes-macrophages stimulated the immune T-cell proliferative response to the multideterminant antigens dinitrophenyl- ovalbumin and keyhole limpet hemocyanin. The implications of these studies and the relationship of leukocytic pyrogen to human lymphocyte- activating factor are discussed.