Parental growth at different life stages and offspring birthweight:: an intergenerational cohort study
Parental growth at different life stages and offspring birthweight:: an intergenerational cohort study
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DOI：
10.1111/j.1365-3016.2004.00556.x
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发表时间：
2004-05-01
影响因子：
2.8
通讯作者：
Smith, GD
中科院分区：
文献类型：
--
作者：
Hyppönen, E;Power, C;Smith, GD
我们利用 1958 年英国全国出生队列的三代人研究了父母体型与后代出生体重的关系。到 41 岁时，4566 名单身女性和 4050 名男性队列成员（出生于 1958 年 3 月 3 日至 9 日）已成为父母，并提供了有关其单身后代的信息。母亲的出生体重（根据胎龄和性别标准化）是后代出生体重的最强决定因素（效应量 [ES] 每 SDS 112 g [95% CI 97, 128]），几乎不受调整的影响母亲身高或 BMI（ES 分别为 95 克和 105 克）。对于出生体重很小或很大的母亲，没有观察到代际出生体重关联。在调整祖父母体型、自身出生体重和成人体型后，母亲 7 岁时的童年身高 (ES 46 g [24, 67]) 而不是 BMI (ES 3 g [-18, 23]) 与后代出生体重相关。控制其他生长指标会强烈削弱母亲成年身高和后代出生体重之间的关联：（ES 90 g，未调整，和 25 g，调整），而成人 BMI 和后代出生体重之间的关联几乎没有受到影响（ES 分别为 55 g 和 51 g）。父亲的体重指数不会影响后代的出生体重，而与身高的相关性与母亲观察到的相关性相似，但较弱。我们的结果表明，出生体重的代际关联在很大程度上与出生后体型无关。母亲童年时期的身高与后代的出生体重呈正相关，而其体重指数的影响仅限于成年期。
Using three generations of the 1958 British national birth cohort we investigated ways in which parental size is related to offspring birthweight. By age 41 years, 4566 singleton female and 4050 male cohort members (born 3-9 March, 1958) had become parents and provided information on their singleton offspring.Mother's birthweight (standardised for gestational age and sex) was the strongest determinant of offspring birthweight (effect size [ES] per SDS 112 g [95% CI 97, 128]), which was little affected by adjustment for maternal height or BMI (ES 95 g and 105 g respectively). The intergenerational birthweight association was not observed for mothers born very small or large. Mother's childhood height at age 7 (ES 46 g [24, 67]), but not BMI (ES 3 g [-18, 23]), was associated with offspring birthweight after adjustment for grandparental size, own birthweight, and adult size. Controlling for other growth measures strongly attenuated the association between mother's adult height and offspring birthweight: (ES 90 g, unadjusted, and 25 g, adjusted), while the association between adult BMI and offspring birthweight was little affected (ES 55 g and 51 g respectively). Father's BMI did not affect offspring birthweight, while the associations for height were similar, albeit weaker, than those observed for the mother. Our results suggest that intergenerational associations in birthweights are largely independent of postnatal size. Maternal height in childhood was positively related to offspring birthweight, while the effect of her BMI was restricted to adulthood.