Pulmonary Leukostasis and Its Relationship to Pulmonary Dysfunction in Sheep and Rabbits
Pulmonary Leukostasis and Its Relationship to Pulmonary Dysfunction in Sheep and Rabbits
复制标题
羊和兔的肺白细胞淤滞及其与肺功能障碍的关系
作者：
S. Fountain;B. Martin;C. Musclow;J. Cooper
作为补体激活的结果，肺白细胞停滞被认为是肺功能障碍的原因之一。为了研究这一现象，我们研究了绵羊和兔子输注自体补体激活血浆后的肺反应。用酵母多糖与血浆孵育产生补体激活。在开始输注血浆后，所有动物都会出现白细胞减少，有选择性地将多形核白细胞送入肺内。补体激活的血浆输注使绵羊动脉血氧分压显著下降，肺血管阻力显著升高，而在兔体内未观察到这种影响。绵羊用亚磺胺吡喃酮处理后，肺对补体激活血浆的反应消失，但不改变白细胞减少反应。兔和绵羊的肺组织学证实，在血浆输注后存在毛细血管内白血球淤积，无论以前是否使用过磺胺吡喃酮。肺对补体激活的反应与肺毛细血管白血球淤滞有关，但单靠白血球淤积不能充分解释这种现象。中国保监会第46号决议：175-180,1980
Pulmonary leukostasis, as a result of complement activation, has been invoked as a cause of pulmonary dysfunction. To investigate this phenomenon, we studied the pulmonary response to infusion of autologous complement-activated plasma in sheep and rabbits. Complement activation was produced by plasma incubation with zymosan. Leukopenia, with selective loss of polymorphonuclear leukocytes into the lungs, occurred in all animals immediately after the onset of plasma infusion. Complement-activated plasma infusion in sheep produced a significant fall in the arterial Po2 and a marked rise in pulmonary vascular resistance, whereas no such effects were observed in rabbits. Pretreatment of the sheep with sulfinpyrazone eliminated the pulmonary response to complement-activated plasma without altering the leukopenic response. Pulmonary histology in rabbits and sheep confirmed the presence of intracapillary leukostasis after the plasma infusions, whether or not sulfin-pyrazone had been administered previously. The pulmonary response to complement activation is associated with pulmonary capillary leukostasis, but leukostasis alone is not an adequate explanation of the phenomenon. Circ Res 46:175-180, 1980