COMBINED SCATTER DIAGRAMS OF SHEATH THICKNESS AND FIBER CALIBER IN HUMAN SURAL NERVES - CHANGES WITH AGE AND NEUROPATHY
COMBINED SCATTER DIAGRAMS OF SHEATH THICKNESS AND FIBER CALIBER IN HUMAN SURAL NERVES - CHANGES WITH AGE AND NEUROPATHY
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DOI：
10.1136/jnnp.48.8.749
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发表时间：
1985-01-01
影响因子：
11
通讯作者：
BEUCHE, W
中科院分区：
文献类型：
--
作者：
FRIEDE, RL;BEUCHE, W
计算机辅助方法可以收集人类腓肠神经活检电子显微照片中纤维轮廓的大量测量结果。该方法基于以 g 比（商轴直径/纤维直径）形式同时显示纤维口径和护套厚度，并重新计算圆形纤维轮廓的所有参数。人们发现人类腓肠神经的小直径和大直径纤维形成不同的群体，其鞘厚度趋势明显不同，成熟模式也不同。神经病的初步数据表明，这种方法可以更好地区分两个人群的损伤程度；它还可以评估再生或髓鞘再生纤维的数量。
A computer-assisted method permits collection of large numbers of measurements of fibre profiles in electron micrographs of human sural nerve biopsies. The method is based on stimultaneous demonstration of fibre calibre and of sheath thickness in terms of the g-ratio (quotient axo diameter/fibre diameter), and on the recalculation of all parameters for circular fibre profiles. The fibres of small and large diameters of human sural nerves were found to form separate populations with distinctly different trends for sheath thickness and also different patterns of maturation. Preliminary data in neuropathy show that this method gives a better distinction of the extent of damage to either of the two populations; it also permits assessment of the number of regenerating or remyelinating fibres.