Inverse spatially offset Raman spectroscopy for deep noninvasive probing of turbid media
Inverse spatially offset Raman spectroscopy for deep noninvasive probing of turbid media
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DOI：
10.1366/000370206778999102
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发表时间：
2006-11-01
影响因子：
3.5
通讯作者：
Matousek, Pavel
中科院分区：
文献类型：
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作者：
Matousek, Pavel
介绍了一种新型的高灵敏度空间偏移拉曼光谱技术（SORS），用于分层混浊介质的深层无损探测。该技术，称为逆SORS，允许更大的深度进行询问比那些可访问的传统SORS的方法。这是通过消除传统SORS方法固有的光谱失真来提高技术的灵敏度来实现的。该方法还允许在存在强度限制的应用中使用更高的激光功率，例如在体内探测人体组织时。此外，新方法具有更高程度的灵活性，使现场剪裁的实验条件，如个别样品的空间偏移的幅度和数量。该方案使用了反向SORS几何形状，从而通过探头中心的光纤收集拉曼光，并通过环形光束将激光辐射传递到样品。该方法被证明是在一个分层的粉末样品和几个实际的例子，它的用途，提出了第一次，也给出。潜在的应用包括疾病诊断，通过包装对药品和化学品的非侵入性探测，对聚合物、生物膜或油漆的探测，以及国土安全筛查。
A new type of highly sensitive spatially offset Raman spectroscopy (SORS) developed for deep noninvasive probing of stratified turbid media is described. The technique, termed inverse SORS, permits much greater depths to be interrogated than those accessible with the conventional SORS approach. This is achieved by enhancing the sensitivity of the technique through the elimination of spectral distortions inherent to the conventional SORS methodology. The method also permits the use of higher laser powers in applications where intensity limits exist, such as when probing human tissue in vivo. In addition, the new approach possesses a much higher degree of flexibility, enabling on-the-spot tailoring of experimental conditions such as the magnitude and number of spatial offsets to individual samples. The scheme uses a reverse SORS geometry whereby Raman light is collected through fibers at the center of the probe and laser radiation is delivered to the sample through a beam in the shape of a ring. The method is demonstrated on a layered powder sample and several practical examples of its uses, presented for the first time, are also given. Potential applications include disease diagnosis, noninvasive probing of pharmaceutical products and chemicals through packaging, probing of polymers, biofilms or paints, and homeland security screening.