Chitosan-based biomaterials for tissue engineering
Chitosan-based biomaterials for tissue engineering
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DOI：
10.1016/j.eurpolymj.2012.12.009
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发表时间：
2013-04-01
影响因子：
6
通讯作者：
Jerome, Christine
中科院分区：
文献类型：
--
作者：
Croisier, Florence;Jerome, Christine
壳聚糖来源于几丁质，是一种独特的生物聚合物，除了生物相容性和生物降解性外，还具有优异的性能。大多数这些特殊的性质是由于沿壳聚糖主链存在伯胺。因此，这种多糖是生物材料领域，特别是组织工程领域的相关候选物。本文重点介绍了新型壳聚糖基生物材料的制备和性能，并对其应用前景进行了展望。讨论了壳聚糖在3d支架中的使用-作为凝胶和海绵-以及在2d支架中的使用-作为薄膜和纤维-特别关注伤口愈合的应用。(c) 2013 Elsevier Ltd.版权所有。
Derived from chitin, chitosan is a unique biopolymer that exhibits outstanding properties, beside biocompatibility and biodegradability. Most of these peculiar properties arise from the presence of primary amines along the chitosan backbone. As a consequence, this polysaccharide is a relevant candidate in the field of biomaterials, especially for tissue engineering. The current article highlights the preparation and properties of innovative chitosan-based biomaterials, with respect to their future applications. The use of chitosan in 3D-scaffolds - as gels and sponges - and in 2D-scaffolds - as films and fibers - is discussed, with a special focus on wound healing application. (c) 2013 Elsevier Ltd. All rights reserved.