Association between osteocalcin and glucose metabolism: a meta-analysis
Association between osteocalcin and glucose metabolism: a meta-analysis
复制标题
骨钙素与葡萄糖代谢之间的关联：荟萃分析
DOI：
10.1007/s00198-015-3197-8
复制
发表时间：
2015-12-01
影响因子：
4
通讯作者：
Liu, J. -M.
中科院分区：
文献类型：
--
作者：
Liu, D. -M.;Guo, X. -Z.;Liu, J. -M.
本荟萃分析旨在探讨骨钙素（Ocn）与空腹血糖（FPG）和糖化血红蛋白（HbA 1c）之间的关系。结果显示，总Ocn和未羧化Ocn（unOcn）均与FPG和HbA 1c呈负相关，且unOcn与FPG的相关性在男性中更为显著。Introduction本研究的目的是使用荟萃分析方法调查Ocn与FPG和HbA 1c之间的关联强度。和科克伦图书馆从2007年到2014年，以确定相关的研究。一个合并的效果大小与95%的置信区间（CI）derived.ResultsThe荟萃分析包括39项研究，涉及23,381名参与者。总Ocn（tOcn）和FPG之间的总体相关性为−0.16（95% CI，−0.19至−0.14），羧化不足Ocn（unOcn）和FPG之间的总体相关性为−0.15（95% CI，−0.20至−0.11）。在Ocn和HbA 1c之间的关联分析中，tOcn和unOcn的合并相关性分别为-0.16（95%CI，-0.18至-0.14）和-0.16（95%CI，-0.23至-0.08）。男性unOcn与FPG之间的相关性程度显着高于女性（r=-0.18，95%CI，-0.21至-0.14;r=-0.09，95%CI，-0. 13至-0.05;相互作用的P < 0.05）。在unOcn和HbA 1c之间也发现了类似的趋势，但无显著性（男性，r=-0.19，95%CI，-0.24至0.14;女性，r=-0.09，95%CI，-0.22至0.04;相互作用P> 0.05）。没有迹象表明显着的出版偏见被发现在任何method.ConclusionsThis荟萃分析表明，unOCN和tOCN是类似的，并与FPG和HbA 1c在人类呈负相关。unOcn和葡萄糖代谢之间的负相关性似乎在男性比女性更明显。
SummaryThis meta-analysis aimed to investigate the associations between osteocalcin (Ocn) and fasting plasma glucose (FPG) and glycated hemoglobin A1c (HbA1c). It was revealed that both total Ocn and undercarboxylated Ocn (unOcn) were negatively related with FPG and HbA1c, and the association of unOcn with FPG was more pronounced in men.IntroductionThe aim of this study was to investigate the strength of associations between Ocn and FPG and HbA1c using a meta-analysis approach.MethodsA search was carried out using the databases of PubMed, ISI Web of Science, and the Cochrane library from 2007 to 2014 to identify related studies. A pooled effect size with 95 % confidence intervals (CI) was derived.ResultsThe meta-analysis included 39 studies involving 23,381 participants. The overall correlation was −0.16 (95 % CI, −0.19 to −0.14) between total Ocn (tOcn) and FPG and −0.15 (95 % CI, −0.20 to −0.11) between undercarboxylated Ocn (unOcn) and FPG. In the analysis of the association between Ocn and HbA1c, the pooled correlation was −0.16 (95 % CI, −0.18 to −0.14) for tOcn and −0.16 (95 % CI, −0.23 to −0.08) for unOcn. The magnitude of the correlation between unOcn and FPG is significantly higher in men than in women (r= −0.18, 95 % CI, −0.21 to −0.14;r= −0.09, 95 % CI, −0. 13 to −0.05, respectively;Pfor interaction < 0.05). Similar trend was also found between unOcn and HbA1c but without significance (for men,r= −0.19, 95 % CI, −0.24 to −0.14; for women,r= −0.09, 95 % CI, −0.22 to 0.04, respectively;Pfor interaction > 0.05). No indication of significant publication bias was found in any method.ConclusionsThis meta-analysis demonstrated that both unOcn and tOcn were similarly and negatively correlated with FPG and HbA1c in humans. The negative correlations between unOcn and glucose metabolism appear to be more pronounced in men than in women.