Cellular "sensing" of extracellular calcium (Ca(2+)(o)): emerging roles in regulating diverse physiological functions.
Cellular "sensing" of extracellular calcium (Ca(2+)(o)): emerging roles in regulating diverse physiological functions.
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DOI：
10.1016/s0898-6568(00)00082-6
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发表时间：
2000-06
影响因子：
4.8
通讯作者：
N. Chattopadhyay;E. Brown
中科院分区：
文献类型：
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作者：
N. Chattopadhyay;E. Brown
细胞外Ca2+(Ca2+o)感应受体（CaR）通过调节甲状旁腺激素（PTH）分泌和肾脏Ca2+处理严重影响Ca2+稳态。此外，它在肠和骨细胞中的表达表明，它在维持全身Ca2+稳态的所有器官中都起作用。这种g蛋白偶联受体也在全身其他细胞中广泛表达。虽然我们对其在Ca2+代谢控制系统之外的作用的理解仍处于初级阶段，但CaR可能会成为多种细胞功能的多功能调节剂，包括增殖、分化、凋亡、基因表达和维持膜电位。最后，最近开发的“拟钙化”CaR激活剂，如NPS R-467和NPS R-568，为治疗以前没有有效药物治疗的疾病提供了新的方法：本综述也涵盖了这个主题。
The extracellular Ca2+(Ca2+o)-sensing receptor (CaR) critically influences Ca2+ohomeostasis by regulating parathyroid hormone (PTH) secretion and renal Ca2+handling. Moreover, its expression in intestinal and bone cells suggests roles in all of the organs involved in maintaining systemic Ca2+ohomeostasis. This G-protein coupled receptor is also expressed in a wide variety of additional cells throughout the body. While our understanding of its role(s) outside of the system governing Ca2+ometabolism remains rudimentary, the CaR will probably emerge as a versatile regulator of diverse cellular functions, including proliferation, differentiation, apoptosis, gene expression and maintenance of membrane potential. Finally, the recently developed, “calcimimetic” CaR activators, exemplified by a NPS R-467 and NPS R-568, provide novel approaches to treating diseases that previously had no effective medical therapies: topic likewise covered in this review.