Effects of adolescent ethanol exposure on sleep in adult rats
Effects of adolescent ethanol exposure on sleep in adult rats
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DOI：
10.1016/j.alcohol.2008.08.001
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发表时间：
2008-12-01
期刊：
影响因子：
2.3
通讯作者：
Ehlers, Cindy L.
中科院分区：
文献类型：
--
作者：
Criado, Jose R.;Wills, Derek N.;Ehlers, Cindy L.
虽然青少年乙醇（EtOH）暴露与脑功能的长期变化有关，但对于青春期乙醇暴露是否会改变睡眠和皮质唤醒知之甚少。本研究检查了青春期暴露于EtOH的成年大鼠睡眠的长期变化。将青春期雄性Wistar大鼠暴露于EtOH蒸汽中，每天12小时，持续5周。皮质脑电图在4小时的记录会议后，5周的退出乙醇。与对照组相比，青少年EtOH暴露显著减少了慢波睡眠（SWS）发作的平均持续时间和暴露于EtOH的大鼠在SWS中花费的总时间。频谱分析显示，青少年EtOH暴露显着增加皮层峰值频率在SWS在2-4，4-6，和6-8 Hz频段。总之，我们的研究结果表明，青春期大鼠的慢性EtOH暴露降低了SWS的测量值，所有影响也被视为正常衰老的一部分。虽然细胞和分子机制介导的后果EtOH暴露在老化过程中是未知的，青少年EtOH暴露和老化之间的相似性值得进一步调查。(C)2008年爱思唯尔公司All rights reserved.
Although adolescent ethanol (EtOH) exposure has been associated with long-lasting changes in brain function, little is known as to whether EtOH exposure during adolescence alters sleep and cortical arousal. This study examined protracted alterations in sleep in adult rats exposed to EtOH during adolescence. Adolescent male Wistar rats were exposed to EtOH vapor for 12 h/day for 5 weeks. Cortical electroencephalograms were obtained during 4-h recording sessions after 5 weeks of withdrawal from EtOH. Adolescent EtOH exposure significantly reduced the mean duration of slow-wave sleep (SWS) episodes and the total amount of time spent in SWS in EtOH-exposed rats, compared to controls. Spectral analysis revealed that adolescent EtOH exposure significantly increased cortical peak frequencies during SWS in the 2-4, 4-6, and 6-8 Hz bands. Taken together, our findings suggest that chronic EtOH exposure in adolescent rats reduces measures of SWS, ail effect also seen as part of normal aging. Although the cellular and molecular mechanisms mediating the consequences of EtOH exposure on the aging process are not known, the similarities between adolescent EtOH exposure and aging merits further investigation. (C) 2008 Elsevier Inc. All rights reserved.