Rising population of survivors of oral squamous cell cancer in the United States
Rising population of survivors of oral squamous cell cancer in the United States
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DOI：
10.1002/cncr.29921
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发表时间：
2016-05-01
期刊：
影响因子：
6.2
通讯作者：
Fakhry, Carole
中科院分区：
文献类型：
--
作者：
Patel, Mira A.;Blackford, Amanda L.;Fakhry, Carole
背景：在美国，口咽癌（OPC）和口腔癌（OCC）的发病率正在上升。据作者所知，到目前为止，尚未对假定的OPC和OCC幸存者的流行率进行调查。方法回顾性分析监测、流行病学和最终结果数据（1975-2012），估计OPC和OCC的发病率、5年病因特异性生存率和患病率的变化。发生率、病因特异性生存率和患病率的变化通过线性回归估计，并表示为百分比变化(B)。随着时间的推移，发病率趋势的差异通过连接点分析确定。结果1975 - 2012年OPC发病率上升62.6%。OPC发病率在男性、白人和年轻人中显著增加。OPC的5年生存率在所有性别、种族和年龄在0 - 30岁的个体中均显著增加，其中白人个体和男性的生存率增幅最大。相比之下，OCC的发病率在同一时期下降了22.3%。OCC发病率在所有组中均有所下降，但在30至39岁的个体中有所增加。除女性、黑人和老年人外，OCC患者的生存率显著提高
BACKGROUNDThe incidence of oropharyngeal cancer (OPC) and a subset of oral cavity cancer (OCC) is increasing in the United States. To the authors' knowledge, the presumed growing prevalence of survivors of OPC and OCC has not been investigated to date.METHODSRetrospective analysis of Surveillance, Epidemiology, and End Results data (1975-2012) estimated changes in incidence, 5-year cause-specific survival, and prevalence for OPC and OCC. Changes in incidence, cause-specific survival and prevalence were estimated by linear regression and expressed as the percentage change (B). Differences in incidence trends over time were determined by joinpoint analysis.RESULTSThe incidence of OPC increased by 62.6% from 1975 through 2012. Notable increases in OPC incidence were observed among men, white individuals, and those of younger ages. The 5-year survival for OPC increased significantly for all sexes, races, and individuals aged >30 years, with white individuals and males experiencing the largest increase in survival. By contrast, the incidence of OCC declined by 22.3% during the same time period. OCC incidence decreased across all groups but increased among individuals aged 30 to 39 years. Significant increases in survival were observed for OCC, except for those who were female, black, and aged