Biomarkers for pediatric pulmonary arterial hypertension - a call to collaborate.
Biomarkers for pediatric pulmonary arterial hypertension - a call to collaborate.
复制标题
DOI：
10.3389/fped.2014.00007
复制
发表时间：
2014
影响因子：
2.6
通讯作者：
Yeager ME
中科院分区：
文献类型：
--
作者：
Colvin KL;Dufva MJ;Delaney RP;Ivy DD;Stenmark KR;Yeager ME
儿童肺动脉高压（PAH）的治疗方法主要基于临床医生的经验，而成人肺动脉高压的治疗方法则以证据为基础。目前明确需要非侵入性和客观的生物标志物来指导儿童该病的准确诊断、治疗和预后。疾病的多面谱、临床表现和与其他疾病的关联使这成为一项艰巨的挑战。然而，随着在了解和管理成人多环芳烃方面取得更多进展，将这些知识应用于儿童的潜力从未如此之大。本文综述了PAH中非侵入性生物标志物的最新进展，着眼于那些可能适用于儿科PAH的成人PAH生物标志物。
Therapeutic approaches in pediatric pulmonary arterial hypertension (PAH) are based primarily on clinician experience, in contrast to the evidence-based approach in adults with pulmonary hypertension. There is a clear and present need for non-invasive and objective biomarkers to guide the accurate diagnosis, treatment, and prognosis of this disease in children. The multifaceted spectrum of disease, clinical presentation, and association with other diseases makes this a formidable challenge. However, as more progress is being made in the understanding and management of adult PAH, the potential to apply this knowledge to children has never been greater. This review explores the state of the art with regard to non-invasive biomarkers in PAH, with an eye toward those adult PAH biomarkers potentially suitable for application in pediatric PAH.
登录
查看更多内容
影响因子：
2.6
作者：
Blalock S;Chan F;Rosenthal D;Ogawa M;Maxey D;Feinstein J
通讯作者：
Feinstein J
影响因子：
3.6
作者：
Abman SH;Ivy DD
通讯作者：
Ivy DD
影响因子：
168.9
作者：
Berger, Rolf M. F.;Beghetti, Maurice;Humpl, Tilman;Raskob, Gary E.;Ivy, D. Dunbar;Jing, Zhi-Cheng;Bonnet, Damien;Schulze-Neick, Ingram;Barst, Robyn J.
通讯作者：
Barst, Robyn J.
影响因子：
9.6
作者：
Boerrigter, Bart;Mauritz, Gert-Jan;Vonk-Noordegraaf, Anton
通讯作者：
Vonk-Noordegraaf, Anton
影响因子：
4.4
作者：
Böger, RH
通讯作者：
Böger, RH