A dual-subsystem model of the brain's default network: Self-referential processing, memory retrieval processes, and autobiographical memory retrieval
A dual-subsystem model of the brain's default network: Self-referential processing, memory retrieval processes, and autobiographical memory retrieval
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DOI：
10.1016/j.neuroimage.2012.03.025
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发表时间：
2012-07-16
期刊：
影响因子：
5.7
通讯作者：
Kim, Hongkeun
中科院分区：
文献类型：
--
作者：
Kim, Hongkeun
大多数内部导向的心理活动都强烈激活默认网络，包括回忆过去，未来思维和社会认知，并且是高度自我参照的，需要记忆提取过程。基于这些观察和相关文献的研究结果，本文提出了一个简单的，双子系统的默认网络模型。该模型估计自传体记忆（AM）检索和相关参考条件下的大脑活动的能力，然后通过进行相关文献的定量荟萃分析进行了测试。该模型将默认网络分为两个子系统。第一个被称为“皮质中线子系统”，由前内侧前额叶皮质和后扣带回皮质组成，主要介导自我参照加工。另一个是顶叶颞叶子系统，包括顶叶下小叶、内侧颞叶和外侧颞叶皮层，主要负责记忆提取过程。AM检索对比的荟萃分析产生了与该模型一致的双重分离。首先，CMS区域与AM >基于实验室的记忆（LM）对比的相关性比与AM >休息对比的相关性更高，这证实这些区域在自我参照处理中比记忆提取过程中发挥着更关键的作用。第二，所有三个PTS区域表现出更大的关联与AM >休息对比比与AM > LM对比，证实了它们在记忆提取过程中的作用大于在自我参照处理。虽然目前的模型是有限的范围内，无论是在解剖和功能规格，它集成了不同的过程，如自我参照加工，情节和语义记忆和子系统接口，并提供有用的解释，可以指导进一步研究的分馏默认网络。(C)2012 Elsevier Inc. All rights reserved.
Most internally oriented mental activities are known to strongly activate the default network, which includes remembering the past, future thinking and social cognition, and are heavily self-referential, and demanding of memory retrieval processes. Based on these observations and building on related findings from the literature, the present article proposed a simple, dual-subsystem model of the default network. The ability of the model to estimate brain activity during autobiographical memory (AM) retrieval and related reference conditions was then tested by performing a quantitative meta-analysis of relevant literature. The model divided the default network into two subsystems. The first, called the 'cortical midline subsystem (CMS)', was comprised of the anteromedial prefrontal cortex and posterior cingulate cortex, and primarily mediates self-referential processing. The other, termed the 'parieto-temporal subsystem (PTS)', included the inferior parietal lobule, medial temporal lobe and lateral temporal cortex, and mainly supports memory retrieval processes. The meta-analysis of AM retrieval contrasts yielded a double dissociation that was consistent with this model. First, CMS regions associated more with an AM > laboratory-based memory (LM) contrast than with an AM > rest contrast, confirming that these regions play more critical roles in self-referential processing than memory retrieval processes. Second, all three PTS regions showed a greater association with an AM > rest contrast than with an AM > LM contrast, confirming that their role in memory retrieval processes is greater than in self-referential processing. Although the present model is limited in scope, both in terms of anatomical and functional specifications, it integrates diverse processes such as self-referential processing, episodic and semantic memory and subsystem interface, and provides useful heuristics that can guide further research on fractionation of the default network. (C) 2012 Elsevier Inc. All rights reserved.