An immunohistochemical study of type I insulin-like growth factor receptors in the placentae of pregnancies with appropriately grown or growth restricted fetuses
An immunohistochemical study of type I insulin-like growth factor receptors in the placentae of pregnancies with appropriately grown or growth restricted fetuses
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DOI：
10.1053/plac.1998.0387
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发表时间：
1999-05-01
期刊：
影响因子：
3.8
通讯作者：
Soothill, P
中科院分区：
文献类型：
--
作者：
Holmes, R;Porter, H;Soothill, P
胰岛素样生长因子（IGFs）及其受体在胎儿体内对生长和产后生存至关重要，但母体IGFs的作用尚不清楚。动物和体外证据表明，母体igf - 1可能对胎盘功能有重要影响。最近的人类研究表明，虽然母体血清igf - 1与胎儿正常生长没有关系，但在胎盘功能障碍导致胎儿生长受限的妊娠期，igf - 1水平很低。一项前瞻性和观察性研究进行了胎盘I型IGF受体（IGF- ir）的分布和浓度在小于胎龄（n=26）或适当生长（n=14）胎儿的妇女。从24周到分娩，每两周扫描一次妇女和病例（出生体重+2 s.d, n=16）和“正常胎龄小”（SGA，正常UAPI，生长速度和羊水，n= 10）。对分娩时获得的福尔摩盐碱固定胎盘活检进行IGF-IR免疫组化。在对照组妊娠中，IGF-IR存在于绒毛内皮和间质、滋养细胞和蜕膜中，其分布和密度在SGA和FGR妊娠中没有变化。我们假设在FGR妊娠中提高母体igf - 1的治疗可能导致胎盘功能增强，从而促进胎儿生长。我们在FGR中胎盘IGF-IR的正常定位和密度的发现鼓励我们将我们的工作扩展到观察母体IGF-I对葡萄糖和氨基酸运输的影响。(c) 1999年；桑德斯有限公司
Insulin-like growth factors (IGFs) and their receptors in the fetus are essential for growth and postnatal survival but the role of maternal IGFs is less well understood. Animal and in vitro evidence suggests that maternal IGF-I may have important effects on placental function. Recent work in humans suggests that although there is no relationship between maternal serum IGF-I and normal fetal growth, levels are low in pregnancies complicated by fetal growth restriction due to placental dysfunction. A prospective and observational study was undertaken of the distribution and concentration of placental type I IGF receptors (IGF-IR) in women with small for gestational age (n=26) or appropriately grown (n=14) fetuses. Women were scanned biweekly from 24 weeks to delivery and cases (birthweight +2 s.d.; n=16) and 'normal small for gestational age' (SGA; normal UAPI, growth velocity and amniotic fluid; n = 10). Immunohistochemistry of the IGF-IR was performed on formol saline-fixed placental biopsies obtained at delivery. In control pregnancies IGF-IR were present in villous endothelium and stroma, trophoblast and decidua and their distribution and density were unchanged in both SGA and FGR pregnancies. We hypothesize that a therapeutic elevation of maternal IGF-I in FGR pregnancy might lead to enhanced placental function and so fetal growth. Our findings of normal localization and density of placental IGF-IR in FGR encourage us to extend our work to look at the effects of maternal IGF-I on the transport of glucose and amino acids. (C) 1999 W. B. Saunders Company Ltd.