Intestinal helminth infections are associated with increased incidence of Plasmodium falciparum malaria in Thailand
Intestinal helminth infections are associated with increased incidence of Plasmodium falciparum malaria in Thailand
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DOI：
10.1645/0022-3395(2002)088
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发表时间：
2002-02-01
影响因子：
1.3
通讯作者：
Looareesuwan, S
中科院分区：
文献类型：
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作者：
Nacher, M;Singhasivanon, P;Looareesuwan, S
在泰国西部边境的5个村庄的总人口的前瞻性研究中，对所有受试者进行了蠕虫感染筛查;在接下来的一年中，记录了疟疾的发病率。患者未接受蠕虫感染治疗。在731名村民中，蠕虫感染的受试者更有可能在次年发生恶性疟疾（调整后的风险比2.24，范围1.4-3.6; P = 0.001）。恶性疟发病风险随寄生虫种类的增多而增加（P = 0.036）。在其他研究中，蠕虫与预防疟疾严重并发症有关，而在这里，蠕虫感染的患者似乎更有可能发展为疟疾。这表明，蠕虫介导的Th 2的转变可能会对疟疾产生复杂的后果，降低抗子孢子免疫，但防止严重的疟疾。
In a prospective study of the total population of 5 hamlets on the western border of Thailand, all subjects were screened for helminth infections; during the following year, the incidence of malaria was recorded. Patients were not treated for helminth infections. Among 731 villagers, helminth-infected subjects were more likely to develop falciparum malaria during the following year (adjusted risk ratio 2.24, range 1.4-3.6; P = 0.001). The risk of developing falciparum malaria increased with the number of helminth species (P = 0.036). Whereas in other studies helminths were associated with protection from severe complications of malaria, it seemed here that helminth-infected patients were more likely to develop malaria. It is suggested that a helminth-mediated Th2 shift may have complex consequences on malaria, decreasing antisporozoite immunity, but protecting against severe malaria.