Potassium channels in peripheral pain pathways: expression, function and therapeutic potential.
Potassium channels in peripheral pain pathways: expression, function and therapeutic potential.
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DOI：
10.2174/1570159x113119990042
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发表时间：
2013-12
影响因子：
5.3
通讯作者：
Gamper N
中科院分区：
文献类型：
--
作者：
Du X;Gamper N
外周躯体感觉神经的电兴奋是哺乳动物神经系统产生大多数疼痛信号的第一步。这种兴奋是由一组复杂的离子通道控制的，这些离子通道被协调以产生与外部刺激强度成比例的兴奋程度。然而，在许多疾病状态下，这种协调被破坏，导致外周兴奋性失调，这反过来可能支持病理性疼痛状态（即偏头痛、神经痛、神经性和炎性疼痛）。钾离子通道是控制神经元兴奋性的主要离子通道之一，本文就钾离子通道在外周痛通路中的作用作一综述。审查的目的有三个。首先，我们将讨论目前的证据表明，在外周伤害性纤维的各种K+通道的表达和功能作用。第二，我们将考虑一个假设，表明减少外周伤害性通路内的K+通道的功能活动是许多类型的疼痛的一般特征。第三，我们将评估的前景，药理学增强钾通道的伤害性通路作为一种策略，新的镇痛药物设计。
Electrical excitation of peripheral somatosensory nerves is a first step in generation of most pain signals in mammalian nervous system. Such excitation is controlled by an intricate set of ion channels that are coordinated to produce a degree of excitation that is proportional to the strength of the external stimulation. However, in many disease states this coordination is disrupted resulting in deregulated peripheral excitability which, in turn, may underpin pathological pain states (i.e. migraine, neuralgia, neuropathic and inflammatory pains). One of the major groups of ion channels that are essential for controlling neuronal excitability is potassium channel family and, hereby, the focus of this review is on the K+ channels in peripheral pain pathways. The aim of the review is threefold. First, we will discuss current evidence for the expression and functional role of various K+ channels in peripheral nociceptive fibres. Second, we will consider a hypothesis suggesting that reduced functional activity of K+ channels within peripheral nociceptive pathways is a general feature of many types of pain. Third, we will evaluate the perspectives of pharmacological enhancement of K+ channels in nociceptive pathways as a strategy for new analgesic drug design.