Who Qualifies for Deep Brain Stimulation for OCD? Data From a Naturalistic Clinical Sample
Who Qualifies for Deep Brain Stimulation for OCD? Data From a Naturalistic Clinical Sample
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DOI：
10.1176/appi.neuropsych.12090226
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发表时间：
2014-12-01
影响因子：
2.9
通讯作者：
Rasmussen, Steven A.
中科院分区：
文献类型：
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作者：
Garnaat, Sarah L.;Greenberg, Benjamin D.;Rasmussen, Steven A.
一些强迫症(OCD)患者尽管竭尽全力地进行最佳实践治疗，但仍然严重受损。对于他们来说，可以考虑进行神经外科手术(立体定向消融或脑深部刺激)。作者调查了寻求治疗的强迫症患者的比例，在一个自然主义的临床样本中，他们符合当代神经外科选择标准。从NIMH支持的布朗纵向强迫症研究中，使用成年患者的诊断、严重程度和治疗史的综合基线数据，325名患者中只有2人符合神经外科的筛查标准。这一发现促使人们考虑在样本有限的情况下进行临床试验的新模式，以及改进此类侵入性治疗的进入标准的方法。
A few patients with obsessive-compulsive disorder (OCD) remain severely impaired despite exhausting best-practice treatments. For them, neurosurgery (stereotactic ablation or deep brain stimulation) might be considered. The authors investigated the proportion of treatment-seeking OCD patients, in a naturalistic clinical sample, who met contemporary neurosurgery selection criteria. Using comprehensive baseline data on diagnosis, severity, and treatment history for adult patients from the NIMH-supported Brown Longitudinal OCD Study, only 2 of 325 patients met screening criteria for neurosurgery. This finding prompts consideration of new models for clinical trials with limited samples as well as methods of refining entry criteria for such invasive treatments.