Fcgamma receptor-mediated induction of dendritic cell maturation and major histocompatibility complex class I-restricted antigen presentation after immune complex internalization.
Fcgamma receptor-mediated induction of dendritic cell maturation and major histocompatibility complex class I-restricted antigen presentation after immune complex internalization.
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DOI：
10.1084/jem.189.2.371
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发表时间：
1999-01-18
影响因子：
15.3
通讯作者：
Amigorena, S
中科院分区：
文献类型：
--
作者：
Regnault, A;Lankar, D;Lacabanne, V;Rodriguez, A;Thery, C;Rescigno, M;Saito, T;Verbeek, S;Bonnerot, C;Ricciardi-Castagnoli, P;Amigorena, S
树突状细胞（DCs）表达免疫球蛋白（IG）G Fc部分（FcγR）的几种受体，其介导抗原-IgG复合物（免疫复合物，IC）的内化并促进有效的主要组织相容性复合物（MHC）II类限制性抗原呈递。我们现在发现，Fcγ R在小鼠DC中具有两个额外的特异性属性：诱导DC成熟和促进来自外源性IgG复合抗原的肽的有效MHC I类限制性呈递。两种FcγR功能都需要Fcγ R相关的γ链。Fcγ R介导的MHC I类限制性抗原提呈对未成熟DC非常敏感和特异。它需要蛋白酶体降解，并依赖于与抗原加工相关的功能性肽转运蛋白TAP 1-TAP 2。通过促进DC成熟和在MHC I类和II类分子上的呈递，IC应该有效地使DC敏感以在体内引发CD 4+辅助性T淋巴细胞和CD 8+细胞毒性T淋巴细胞。
Dendritic cells (DCs) express several receptors for the Fc portion of immunoglobulin (Ig)G (FcγR), which mediate internalization of antigen–IgG complexes (immune complexes, ICs) and promote efficient major histocompatibility complex (MHC) class II–restricted antigen presentation. We now show that FcγRs have two additional specific attributes in murine DCs: the induction of DC maturation and the promotion of efficient MHC class I–restricted presentation of peptides from exogenous, IgG-complexed antigens. Both FcγR functions require the FcγR-associated γ chain. FcγR-mediated MHC class I–restricted antigen presentation is extremely sensitive and specific to immature DCs. It requires proteasomal degradation and is dependent on functional peptide transporter associated with antigen processing, TAP1-TAP2. By promoting DC maturation and presentation on both MHC class I and II molecules, ICs should efficiently sensitize DCs for priming of both CD4+ helper and CD8+ cytotoxic T lymphocytes in vivo.