TREX1 dictates the immune fate of irradiated cancer cells
TREX1 dictates the immune fate of irradiated cancer cells
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DOI：
10.1080/2162402x.2017.1339857
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发表时间：
2017-01-01
期刊：
影响因子：
7.2
通讯作者：
Demaria, Sandra
中科院分区：
文献类型：
--
作者：
Vanpouille-Box, Claire;Formenti, Silvia C.;Demaria, Sandra
诱导抗肿瘤免疫的最佳辐射剂量和分割仍然难以捉摸。我们最近发现，核酸外切酶TREX 1通过降解干扰素刺激性胞质dsDNA来消除辐射癌细胞的免疫原性。超过10- 12 Gy阈值的每部分辐射剂量的TREX 1上调导致与免疫检查点阻断剂的协同作用差。
The optimal radiation dose and fractionation to induce anti-tumor immunity remain elusive. We recently found that the exonuclease TREX1 abrogates the immunogenicity of irradiated cancer cells by degrading interferon-stimulatory cytosolic dsDNA. TREX1 upregulation by radiation dose per fraction beyond a threshold of 10-12Gy results in poor synergy with immune checkpoint blockers.