Translation regulation in plants: an interesting past, an exciting present and a promising future
Translation regulation in plants: an interesting past, an exciting present and a promising future
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DOI：
10.1111/tpj.13520
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发表时间：
2017-05-01
期刊：
影响因子：
7.2
通讯作者：
Alonso, Jose M.
中科院分区：
文献类型：
--
作者：
Merchante, Catharina;Stepanova, Anna N.;Alonso, Jose M.
基因表达的变化是大多数生物过程的核心，从细胞分化到器官发育，包括整个生物体对不断变化的环境的适应。尽管转录调控的中心作用已经被牢固地确立，并且参与这种类型调控的一般机制也被相对较好地理解，但很明显，翻译水平的调控在调节基因表达中也起着重要作用。尽管有大量的例子说明了翻译调控在决定基因表达水平方面所起的关键作用，但我们对此类调控背后的分子机制的理解一直缓慢出现。随着近年来高通量方法的发展，映射和量化不同的关键参数影响翻译，如RNA结构，蛋白质-RNA相互作用和核糖体占用在基因组水平上，对研究翻译调控的新的热情是必要的。在完善的和未表征的翻译依赖过程中使用这些新的强大技术，有望破译翻译调控背后可能复杂多样但也令人着迷的机制。
Changes in gene expression are at the core of most biological processes, from cell differentiation to organ development, including the adaptation of the whole organism to the ever-changing environment. Although the central role of transcriptional regulation is solidly established and the general mechanisms involved in this type of regulation are relatively well understood, it is clear that regulation at a translational level also plays an essential role in modulating gene expression. Despite the large number of examples illustrating the critical role played by translational regulation in determining the expression levels of a gene, our understanding of the molecular mechanisms behind such types of regulation has been slow to emerge. With the recent development of high-throughput approaches to map and quantify different critical parameters affecting translation, such as RNA structure, protein-RNA interactions and ribosome occupancy at the genome level, a renewed enthusiasm toward studying translation regulation is warranted. The use of these new powerful technologies in well-established and uncharacterized translation-dependent processes holds the promise to decipher the likely complex and diverse, but also fascinating, mechanisms behind the regulation of translation.